APOL1 nephropathy – a population genetics success story
Orly Tabachnikov,
Karl Skorecki,
Etty Kruzel-Davila
Abstract:Purpose of review
More than a decade ago, apolipoprotein L1 (APOL1) risk alleles designated G1 and G2, were discovered to be causally associated with markedly increased risk for progressive kidney disease in individuals of recent African ancestry. Gratifying progress has been made during the intervening years, extending to the development and clinical testing of genomically precise small molecule therapy accompanied by emergence of RNA medicine platforms and clinical testing within just over a deca… Show more
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