APOE ε4 positivity predicts centrality of episodic memory nodes in patients with mild cognitive impairment: A cohort-based, graph theory-informed study of cognitive networks
Abstract:Published research reports inconsistent links between APOE-ε4 and cognition. We hypothesised that these links can be reliably captured by graph-theory analyses.Cognitive networks were calculated in 8,118 controls, 3,482 MCI patients and 4,573 Alzheimer’s dementia patients, recruited as part of the National Alzheimer’s Coordinating Center (NACC) initiative. Differences in nodal centrality were tested in two independent NACC sub-cohorts between ε4-carriers and non-carriers.A significant APOE-dependant effect eme… Show more
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