ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

Sun, Shoudan; Fu, Jingming; Chen, Jun; Pang, Wei Wei; Hu, Ruomei; Li, Haiqiang; Tan, Lei; Jiang, Yugang

doi:10.1177/1533317514566114

Cited by 5 publications

(4 citation statements)

References 32 publications

(37 reference statements)

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“…In a Korean population, APOE genotype was not associated with age-related cognitive decline [ 23 ] (though it was associated with Alzheimer’s disease risk [ 24 ]). By contrast, studies of Chinese elders found that APOE was associated with age-related cognitive decline [ 25 ], as well as cross-sectional cognitive ability [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults

et al. 2018

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Apolipoprotein E (APOE) genotype is believed to play a role in the onset of dementia, though less is known about its relationship with non-pathogenic age-related cognitive decline. We assessed whether APOE was a risk factor for cognitive decline among older Taiwanese adults using nationally representative data. General cognition was measured longitudinally over eleven years; domain-specific cognitive assessments of working memory, declarative learning and three aspects of attention (executive function, alerting, and orientation) were performed once. Having at least one risky APOE allele was associated with more rapid longitudinal cognitive decline compared to those with no risky alleles. Some evidence from the cross-sectional analysis of domain-specific cognitive assessments suggested that APOE genotype may be more closely associated with working memory and declarative learning than with attention. Most genetic studies of cognition include only populations of European descent; extension is crucial. This study confirmed the association between APOE genotype and the rate of cognitive decline in a predominantly Han Chinese population. Additional studies on diverse populations are warranted.

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults

et al. 2018

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“…In the current study, the APOE ε4 allele is not associated with the MMSE score in Chinese older adults. Although some studies form western countries (e.g., Northern Europe) have found APOE ε4-related decline in global cognitive function [35,36], the population-based study failed to observe a signi cant association of APOE ε4 allele with MMSE score in Chinese older adults [37]. Of note, compared to the proportion of people carrying APOE ε4 allele in the Nordic population (around 25-30%), the proportion in our study is relatively low (14.9%), and only 1.4% carried the homozygote 4 allele.…”

Section: Associations Of Apoe ε4 Allele Tomm40 G Allele With Cognitimentioning

confidence: 88%

Associations of vascular risk factors, APOE ɛ4 allele, and TOMM40 G allele with cognitive function in Chinese older adults: a community-based study

Gui¹,

Qiu²,

Li³

2020

Preprint

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Background : The associations of vascular risk factors (VRFs) , apolipoprotein E (APOE) ɛ4 allele, and translocase of outer mitochondrial membrane 40 (TOMM40) G allele with cognitive function have been investigated mostly in western societies. In the present study, we sought to examine the associations of VRFs, APOE ε4 allele, and TMM40 G allele (rs2075650) with global cognitive function among Chinese older adults, with a focus on potential interactions between VRFs and the susceptibility genes. Methods : This is a cross-sectional study that included 422 participants (mean age 69.2 years, 54.3% female) in the China Longitudinal Ageing Study , who were free of dementia. Data were collected through interviews, clinical examinations, and laboratory tests. The clustering of multiple VRFs was scored by counting the number of VRFs potentially related to cognitive function. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Data were analyzed with multiple general linear regression models. Results : Physical inactivity and diabetes were independently associated with performance lower MMSE score ( p <0.05). Moreover, physical inactivity interacted with APOE ε4 and TOMM40 G allele (rs2075650), and diabetes interacted with TOM40 G allele to affect cognitive function, such that having physical inactivity in combination with either APOE ε4 allele or TOMM40 G allele, or having diabetes and TOMM40 G allele, compared to having neither, was significantly associated with markedly lower MMSE scores ( p <0.05). Finally, when four modifiable VRFs (i.e., current smoking, physical inactivity, high LDL-C, and diabetes) were aggregated, an increasing number of having these factors was associated with a decreasing MMSE score in a dose-response manner ( p for trend<0.05). Conclusion : Some VRFs (e.g., physical inactivity and diabetes), when concurrently occurring with APOE ε4 or TOMM40 G allele, are associated with substantially poor performance in global cognitive function among the Chinese elderly .

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“…E4 has been related most strongly to global cognition as well as to specific cognitive domains like episodic memory (Marioni et al, 2016;Small et al, 2004), executive function, and processing speed (Luciano et al, 2009;Marioni et al, 2016;Wisdom et al, 2011). Other studies have also linked e4 status to worse working memory, visuospatial attention, perceptual speed, and visual memory in older nondemented subjects (Caselli et al, 2004;Greenwood, Sunderland, Friz, & Parasuraman, 2000;Lim et al, 2012;Sun et al, 2015). Nevertheless, reports remain inconsistent in this matter (Caselli et al, 2004;Devanand et al, 2005;Nilsson, Nyberg, & Ba¨ckman, 2002;Small et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…APOE e4 allele frequency is also significantly higher in other neurodegenerative diseases, including Lewy body dementia (Tsuang et al, 2013), frontotemporal degeneration (Rubino et al, 2013), Parkinson's disease with dementia (Tsuang et al, 2013), and vascular dementia (Yin et al, 2012). Being a major lipid transporter in the brain, APOE among others impacts neuronal plasticity and repair, and the e4 isoform is believed to negatively affect these processes (Arendt et al, 1997;Li et al, 2015;Mauch et al, 2001;Teter et al, 2002;White, Nicoll, Roses, & Horsburgh, 2001). Moreover, it may also be related to cognitive impairment through brain damage provoked by atherosclerosis (Davignon, Cohn, Mabile, & Bernier, 1999;Mahley, Weisgraber, & Huang, 2009).…”

Section: Introductionmentioning

confidence: 99%

The Association of Apolipoprotein E Gene Polymorphism With Cognitive Performance in Nondemented Polish Adults Aged 55 to 75

Piskunowicz

Linkowska

Gołota

et al. 2017

Int J Aging Hum Dev

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The ε4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for dementia. How APOE ε polymorphism affects cognitive performance in nondemented aging subjects remains less clear. In this study, the relationship between APOE status and cognitive performance across various cognitive domains in adults aged 55 to 75 years ( n = 74) without dementia was investigated. E4 carriers ( n = 11) performed worse versus noncarriers on forward Digit Span and delayed recall of the Rey-Osterrieth complex figure. General linear model analysis revealed a small but significant main effect of ε4 on Rey-Osterrieth complex figure delayed recall. Comparing ε2 carriers, ε3 homozygotes, and ε4 carriers, ε3/ε3 performed significantly better on Trail Making Test part B and derived score Trail Making Test B-A. The findings support the relation between the APOE ε polymorphism and visual memory, short-term auditory memory, visuospatial attention, and executive functions in an aging sample without dementia.

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ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

Cited by 5 publications

References 32 publications

Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults

Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults

Associations of vascular risk factors, APOE ɛ4 allele, and TOMM40 G allele with cognitive function in Chinese older adults: a community-based study

The Association of Apolipoprotein E Gene Polymorphism With Cognitive Performance in Nondemented Polish Adults Aged 55 to 75

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