ApoE isoform modulates effects of cranial 56Fe irradiation on spatial learning and memory in the water maze

Yeiser, Lauren A.; Villasana, Laura; Raber, Jacob

doi:10.1016/j.bbr.2012.09.029

Cited by 25 publications

(10 citation statements)

References 25 publications

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“…Previous studies have investigated short- and long-term effects of pre-training/learning irradiation on learning and memory involving the hippocampus and cortex [1–11] and behaviors mediated by the dopamine reward system [12–15]. Compared to studies assessing cognitive function three months or longer following irradiation [12, 14, 16–18], fewer studies have examined earlier effects of irradiation on brain function. Manda et al showed that 56 Fe (1.5 Gy at 500 MeV/n) increased the time male wild-type mice needed to locate the hidden platform in the water maze 30 days following irradiation but not at earlier time points [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex

Kugelman

Zuloaga

Weber

et al. 2016

Behavioural Brain Research

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The brain might be exposed to irradiation under a variety of situations, including clinical treatments, nuclear accidents, dirty bomb scenarios, and military and space missions. Correctly recalling tasks learned prior to irradiation is important but little is known about post-learning effects of irradiation. It is not clear whether exposure to X-ray irradiation during memory consolidation, a few hours following training, is associated with altered contextual fear conditioning 24 hours after irradiation and which brain region(s) might be involved in these effects. Brain immunoreactivity patterns of the immediately early gene c-Fos, a marker of cellular activity was used to determine which brain areas might be altered in post-training irradiation memory retention tasks. In this study, we show that post-training gamma irradiation exposure (1 Gy) enhanced contextual fear memory 24 hours later and is associated with reduced cellular activation in the infralimbic cortex. Reduced GABA-ergic neurotransmission in parvalbumin-positive cells in the infralimbic cortex might play a role in this post-training radiation-enhanced contextual fear memory.

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Section: Introductionmentioning

confidence: 99%

Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex

Kugelman

Zuloaga

Weber

et al. 2016

Behavioural Brain Research

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“…Hippocampal sensitivity to radiation-induced cognitive injury is not limited to gamma irradiation and is also seen 2 weeks (Haley et al, 2012, 2013) or later (Shukitt-Hale et al, 2000; Villasana et al, 2010, 2011; Raber et al, 2011; Yeiser et al, 2013) following 56 Fe irradiation. In all these studies, the animals were trained and tested for hippocampal function following irradiation.…”

Section: Introductionmentioning

confidence: 99%

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Marzulla

Raber

2014

Front. Behav. Neurosci.

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Because of the use of radiation in cancer therapy, the risk of nuclear contamination from power plants, military conflicts, and terrorism, there is a compelling scientific and public health interest in the effects of environmental radiation exposure on brain function, in particular hippocampal function and learning and memory. Previous studies have emphasized changes in learning and memory following radiation exposure. These approaches have ignored the question of how radiation exposure might impact recently acquired memories, which might be acquired under traumatic circumstances (cancer treatment, nuclear disaster, etc.). To address the question of how radiation exposure might affect the processing and recall of recently acquired memories, we employed a fear conditioning paradigm wherein animals were trained, and subsequently irradiated (whole-body X-ray irradiation) 24 h later. Animals were given 2 weeks to recover, and were tested for retention and extinction of hippocampus-dependent contextual fear conditioning or hippocampus-independent cued fear conditioning. Exposure to irradiation following training was associated with reduced daily increases in body weights over the 22-days of the study and resulted in greater freezing levels and aberrant extinction 2 weeks later. This was also observed when the intensity of the training protocol was increased. Cued freezing levels and measures of anxiety 2 weeks after training were also higher in irradiated than sham-irradiated mice. In contrast to contextual freezing levels, cued freezing levels were even higher in irradiated mice receiving 5 shocks during training than sham-irradiated mice receiving 10 shocks during training. In addition, the effects of radiation on extinction of contextual fear were more profound than those on the extinction of cued fear. Thus, whole-body irradiation elevates contextual and cued fear memory recall.

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“…Space radiation exposure, including 56 Fe exposure, poses a significant risk to the central nervous system. In rodents, 56 Fe irradiation might affect hippocampus-dependent cognitive function (Rabin et al 2002(Rabin et al , 2004(Rabin et al , 2009Rola et al 2004;Villasana et al 2010;Haley et al 2012Haley et al , 2013Yeiser et al 2013). ROS are altered by irradiation (Mizumatsu et al 2003;Monje et al 2003;Limoli et al 2007;Manda et al 2008;Tseng et al 2013) and, in this way, affect brain function as well.…”

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confidence: 99%

Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species

Villasana

Weber

Akinyeke

et al. 2016

Journal of Neurochemistry

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Apolipoprotein E (apoE), involved in cholesterol and lipid metabolism, also influences cognitive function and injury repair. In humans, apoE is expressed in three isoforms. E4 is a risk factor for age-related cognitive decline and Alzheimer’s disease, particularly in women. E4 might also be a risk factor for developing behavioral and cognitive changes following 56Fe irradiation, a component of the space environment astronauts are exposed to during missions. These changes might be related to enhanced generation of reactive oxygen species (ROS). In this study, we compared the behavioral and cognitive performance of sham-irradiated and irradiated wild-type (WT) mice and mice expressing the human E3 or E4 isoforms, and assessed the generation of ROS in hippocampal slices from these mice. E4 mice had greater anxiety-like and conditioned fear behaviors than WT mice, and these genotype differences were associated with greater levels of ROS in E4 than WT mice. The greater generation of ROS in the hippocampus of E4 than WT mice might contribute to their higher anxiety levels and enhanced fear conditioning. In E4, but not wild-type, mice, PMA-treated hippocampal slices showed more DHE oxidation in sham-irradiated than irradiated mice and hippocampal HO-1 levels were higher in irradiated than sham-irradiated E4 mice.

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ApoE isoform modulates effects of cranial 56Fe irradiation on spatial learning and memory in the water maze

Cited by 25 publications

References 25 publications

Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex

Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex

Impairment in Extinction of Contextual and Cued Fear Following Post-Training Whole-Body Irradiation

Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species

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