“…The associations of high Glx, mI, and GABA with low episodic memory performance did not remain significant after correction for multiple testing and, thus, need to be interpreted with caution. However, as mI is considered to be a glial marker of inflammation that has been reported to be increased in AD (Bitsch, et al, 1999,Miller, et al, 1993, and Glx, and GABA reflect activity of major cerebral neurotransmitter systems that also are affected by AD pathology (Gomar, et al, 2014,Kapogiannis and Mattson, 2011,Miller, et al, 1993,Olson, et al, 2008,Riese, et al, 2015, our findings might indicate a general increase of neuronal metabolic activity in a context of low episodic memory and thus be consistent with the effects observed for NAA. The fact that metabolic change was not associated with hippocampal or general brain atrophy may indicate potential reversibility due to absence of major neurodegenerative damage.…”