APOE gene polymorphisms and response to statin therapy

Ζιντζαράς, Ηλίας; Kitsios, Georgios D.; Triposkiadis, Filippos; Lau, Joseph; Raman, Gowri

doi:10.1038/tpj.2009.25

Cited by 52 publications

(35 citation statements)

References 40 publications

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“…However, a future meta-analysis of multiple studies clearly has a role in offering an analysis with the potential for higher power. 28,29 Future collaborative studies may allow the pooling of data, providing more power to detect significant associations. Furthermore, consortia performing gene-candidate or genome-wide association studies will be able to replicate the validity of the present findings.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

et al. 2009

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Toll-like receptors (TLRs) and myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms may be involved in the pathogenesis of Hodgkin's lymphoma (HL) through altered immunoregulatory and inflammatory responses. A candidate-gene association study was conducted to investigate the association between TLR9 À1237T4C, TLR9 2848A4G, MYD88 À938C4A and MYD88 1944C4G gene polymorphisms and the risk for HL. The impact of haplotypes was also examined. The study showed that carriership for À1237C and 2848A was associated with an increased risk for HL (odds ratio (OR)¼2.53 (1.36-4.71) and OR¼6.20 (1.3-28.8)). The MYD88 polymorphisms produced nonsignificant results. The estimated frequencies of the TLR9/1237C-2848A and MYD88/938C-1944G haplotypes were also significantly different between HL and controls (Po0.01). In addition, a significant difference between HL and controls was observed for the TLR9/1237C-TLR9/ 2848A-MYD88/938C-MYD88/1944C haplotypes (Po0.01). In conclusion, our study showed that TLR polymorphisms, and TLR9 and MYD88 haplotypes are related to the development of HL.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

et al. 2009

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“…Also, in a study by Zintzaras et al, 21 the results were not significant regarding the relationship between the genetic variants of APOE and plasma lipid levels. However, in a study by Smart et al, 22 variants of genes of lipoprotein lipase, namely CETP-Taq1B, APO E, APOA5, APOA4 and APOC3, were associated with plasma levels of healthy pediatric populations.…”

Section: (1) Association Of Genetic Variation Of Abcb1mentioning

confidence: 77%

Single-nucleotide polymorphisms: a perspective of cardiovascular prevention

Grezzana

Vieira

Portal

2015

Rev. Assoc. Med. Bras.

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Grezzana GB et al. 458 reV assoC med Bras 2015; 61 (5) Results: in order to perform this analysis, 19 studies were included from a total of 89 identified citations. The evaluation of the results suggests that low plasmatic levels of LDL-c are associated with a reduction in the risk of heart attacks, although this was not observed for the rise of plasmatic levels of HDL-c. Conclusion: polymorphisms in different populations and clinical perspectives may bring important contributions for a better understanding and adequacy of plasmatic lipoproteins aiming at reducing cardiovascular risk.

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“…In fact, Sedano et al [8] point out that most studies that have found an association between the e4 allele and most aggressive forms of MS were carried out in Northern Europe [5,15,16,17,18], and most studies that failed to find an association were carried out in Southern Europe [7,8,9,11]. Environmental factors like diet might act on the ApoE gene and explain these differences, as has been proposed in publications about the response to treatment with statins [27]. …”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein Alleles and the Response to Interferon-β-1b in Multiple Sclerosis

et al. 2011

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Background: Results for the e4/e2 alleles of the ApoE gene as markers of susceptibility, clinical and radiological progression, and cognitive deterioration in patients with multiple sclerosis (MS) are contradictory. Aim: The usefulness of these markers in predicting the response to interferon-β-1b (IFNβ-1b) was evaluated. Material and Methods: 95 patients with relapsing-remitting MS treated with IFNβ-1b (mean follow-up 7.44 years) were studied. We correlated the e4 and e2 alleles with the time to the first relapse or to a 1-point worsening on the Expanded Disability Status Scale, time to moderate disability, progression index, and treatment discontinuation due to inefficacy. Results: We found no association between the e4 allele and any of the variables. The e2 allele was associated with increased time to moderate disability. Conclusion: The e4 allele of ApoE has no prognostic value for the response to IFNβ-1b. The e2 allele delayed the progression of disability in our MS patient cohort.

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APOE gene polymorphisms and response to statin therapy

Cited by 52 publications

References 40 publications

Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

Single-nucleotide polymorphisms: a perspective of cardiovascular prevention

Apolipoprotein Alleles and the Response to Interferon-β-1b in Multiple Sclerosis

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