ApoE Epsilon4 Allele and Disease Duration Affect Verbal Learning in Mild Temporal Lobe Epilepsy

Gambardella, Antonio; Aguglia, Umberto; Chifari, R.; Labate, Angelo; Manna, Ida; Serra, P.; Romeo, Nelide; Grazia, S. Della; LePiane, Emilio; Russa, Antonella La; Ventura, Paolo; Cittadella, Rita; Sasanelli, Francesco; Colosimo, Eleonora; Leggio, Ugo; Zappia, Mario; Quattrone, Aldo

doi:10.1111/j.0013-9580.2005.15804.x

Cited by 49 publications

(46 citation statements)

References 53 publications

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“…Apolipoprotein E (ApoE), a major component of very low-Q4 density lipoproteins, has a fundamental modulating function in the central nervous system (CNS) such as mobilization and redistal confusion [4][5][6][7][8]. However, other studies fail to replicate these findings [9,10].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B

Huang

Yan

Lei

et al. 2015

Neuroscience Letters

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B

Huang

Yan

Lei

et al. 2015

Neuroscience Letters

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“…5,6 It has also been associated with deficits in verbal learning following traumatic brain injury (TBI) and in patients with mild temporal lobe epilepsy (TLE). 7,8 Several studies have examined the effect of the ε4 allele of APOE on disease progression in MS with conflicting results. [9][10][11][12] Two studies have investigated the effect of ε4 on cognitive function in MS in the Italian population.…”

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confidence: 99%

“…This was also the case with previous studies on patients with MS and with studies on TLE and TBI. 7,8,13,14 The evidence present in the literature concerning the effect of APOE ε4 on memory function in normal subjects is controversial. In a meta-analysis of 38 studies on the effect of APOE on cognitive performance in normal subjects a small deleterious effect of ε4 on episodic memory was detected.…”

mentioning

confidence: 99%

APOE ε4 is associated with impaired verbal learning in patients with MS

Πάνας¹,

Giogkaraki²,

Potagas³

et al. 2007

Neurology

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“…Intractable temporal lobe epilepsy with senile plaques in epileptogenic focus had a 70% ApoE ε4 carrier frequency as compared to 27% among age-matched controls without senile plaques [28]. ApoE ε4 allele and disease duration affect verbal learning in mild temporal lobe epilepsy [29].…”

Section: Discussionmentioning

confidence: 92%

Association of refractory complex partial seizures with a polymorphism of ApoE genotype

et al. 2005

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Epilepsy is a common disorder affecting up to 1% of the population. Complex partial seizures (CPS) occur in about 35% of patients with epilepsy. Twenty percent of patients with CPS have uncontrolled seizures, refractory to anticonvulsant therapy. The etiology of epilepsy is often multifactorial, with 60-70% of all cases without clear cause, although much is known about the physiological bases of abnormal discharges accompanying seizure phenomena. It seems likely that there is a primary defect in the neuronal membrane that results in the instability of the resting membrane potential [1]. There is no clear biological Abstract Apolipoprotein E (ApoE) is a constituent of many types of lipoproteins that play a role in metabolism of cholesterol and lipids in the body as well as in the brain. ApoE is synthesised in astrocytes and microglia and enter to neurons through LDL, LRP and VLDL receptors. Recently it was shown that ApoE is also produced in neurons. ApoE has a role in modulating learning and memory, structural plasticity, mobilization of cholesterol in repair, growth and maintenance of myelin and neuronal membranes during development and aging, and cell death after ischemic, convulsive, or other type of brain injury. The aim of this research was to investigate the possible association of ApoE gene polymorphism with the development of resistance to pharmacological therapy in patients with partial complex seizures with or without secondary generalization. In this prospective matched-pair controlled study, 60 patients with cryptogenic epilepsy with complex partial seizures, with or without secondary generalization, who have been suffering for five or more years, were studied. The first group comprised 30 patients refractory to the current therapy, while the second group consisted of patients with well-controlled seizures. The refractory and non-refractory groups of patients differed significantly in their phenotypes. Phenotype E3/4 was six times more frequent in refractory group than among non-refractory group. The lack of response was shown to be significantly associated with the presence of ε4 allele. This study provided evidence that the presence of ε4 allele is more often associated with a lack of response to current antiepileptic drugs as compared to ε2 and ε3 alleles.

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ApoE Epsilon4 Allele and Disease Duration Affect Verbal Learning in Mild Temporal Lobe Epilepsy

Abstract: These results provide evidence for an alteration in cognitive performance as a function of the presence of the ApoE epsilon4 allele and point to the critical role of disease duration itself for cognitive impairment in TLE.

Cited by 49 publications

References 53 publications

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B

APOE ε4 is associated with impaired verbal learning in patients with MS

Association of refractory complex partial seizures with a polymorphism of ApoE genotype

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