APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits

Schönknecht, Yannik Bernd; Crommen, Silke; Stoffel‐Wagner, Birgit; Coenen, Martin; Fimmers, Rolf; Stehle, Peter; Ramı́rez, Alfredo; Egert, Sarah

doi:10.3390/nu13113924

Cited by 4 publications

(4 citation statements)

References 35 publications

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“… 234 Clinical studies in aging volunteers report salutary effects of long-term dietary interventions on brain health. 235 , 236 In older adults free from metabolic disorder and memory impairments, participants assigned to a 30% reduced calorie diet for 3 months exhibited improved memory scores compared to the control diet group. 237 Similarly, calorically restricted postmenopausal with obesity exhibited improved memory function as well as increased gray matter volume in the inferior frontal gyrus and hippocampus as well as enhanced functional connectivity in the hippocampus compared to a control group.…”

Section: Emerging Directions For Interventionsmentioning

confidence: 99%

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck,

Morris,

Stanford

2024

DNND

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Obesity is increasing in prevalence across all age groups. Long-term obesity can lead to the development of metabolic and cardiovascular diseases through its effects on adipose, skeletal muscle, and liver tissue. Pathological mechanisms associated with obesity include immune response and inflammation as well as oxidative stress and consequent endothelial and mitochondrial dysfunction. Recent evidence links obesity to diminished brain health and neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Both AD and PD are associated with insulin resistance, an underlying syndrome of obesity. Despite these links, causative mechanism(s) resulting in neurodegenerative disease remain unclear. This review discusses relationships between obesity, AD, and PD, including clinical and preclinical findings. The review then briefly explores nonpharmacological directions for intervention.

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Section: Emerging Directions For Interventionsmentioning

confidence: 99%

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck,

Morris,

Stanford

2024

DNND

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“…Various studies have been conducted in individuals with metabolic syndrome in which the concentrations of oxidative stress biomarkers and antioxidant enzyme activity were measured simultaneously. The findings reveal that the presence of metabolic syndrome is related to an increase in oxidative stress biomarkers and a decrease in antioxidant capacity, which shows that metabolic syndrome is linked to a pro-inflammatory state and poor health as part of a very complex process driving cardiometabolic diseases [14,[203][204][205][206][207].…”

Section: Biomarkers Of Oxidative Stress In Metabolic Syndromementioning

confidence: 99%

Mechanisms of Oxidative Stress in Metabolic Syndrome

Masenga

Kabwe

Chakulya

et al. 2023

IJMS

114

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Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.

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“…Responses after a meal are variable in duration and extent and are regulated by physiological, dietary and genetic determinants, such as APOE gene polymorphisms. A greater inflammatory response was observed in ε4 carriers compared to ε3 overweight elderly people [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy

Stolfo

Pacilli

Seripa

et al. 2023

JCM

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Introduction. Atherosclerosis is a complex multifactorial disease and apolipoprotein E (APOE) polymorphism has been associated with cardiovascular events. The APOE gene, located on chromosome 19q13.2, has an important role in lipid metabolism, in particular on circulating cholesterol levels, implying further pleiotropic effects; from its polymorphism are derived three alleles (ε2, ε3 and ε4), which induce different phenotypes, while its impact on carotid and femoral atherosclerosis is still controversial. Objectives. The aim of the study is to investigate the relationship between APOE genotypes and peripheral revascularization in a cohort of patients affected by advanced peripheral arterial disease (PAD) at a prolonged follow-up. Materials and methods. Some 332 patients (259 males and 73 females; mean age 70.86 ± 7.95 years) with severe PAD were enrolled in a longitudinal study, with a 90.75 ± 32.25 month follow-up, assessing major adverse cardiovascular events (MACE). Results. As compared with ε3/ε3, in ε4 patients we observed a significant higher incidence of carotid (13.2% vs. 5.6%; HR = 2.485, 95% CI 1.062–5.814; p = 0.036) and lower limb (11.8% vs. 4.3%; HR = 2.765, 95% CI 1.091–7.008; p = 0.032) revascularizations and, accordingly, a higher incidence of total peripheral revascularizations (13.5% vs. 9.5%; HR = 2.705, 95% CI 1.420–5.151; p = 0.002). HR remained statistically significant even when adjusted for classic cardiovascular risk factors. Conclusions. In our observational study, we confirm that the ε4 allele is associated with higher total peripheral revascularization in patients with advanced atherosclerotic vascular disease at prolonged follow-up.

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APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits

Cited by 4 publications

References 35 publications

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Mechanisms of Oxidative Stress in Metabolic Syndrome

Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy

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