APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-Adult-study.

Rodriguez, Francisca S.; Schroeter, Matthias L.; Arélin, Katrin; Witte, A. Veronica; Baber, Ronny; Burkhardt, Ralph; Engel, Christoph; Löffler, Markus; Thiery, Joachim; Villringer, Arno; Luck, Tobias; Riedel‐Heller, Steffi G.

doi:10.1037/hea0000515

Cited by 14 publications

(15 citation statements)

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“…9,10 There have been instances of null results, however. 11 It is also possible that there is a degree of file-drawer where null results are less likely to be published. 12 There have been few large-scale systematic investigations into whether APOE e4 interacts with lifestyle risk factors associated with worse cognitive abilities in a single cohort with a standard methodologic procedure.…”

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confidence: 99%

Assessing for interaction betweenAPOEε4, sex, and lifestyle on cognitive abilities

Lyall¹,

Celis‐Morales²,

Graham³

et al. 2019

Neurology

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ObjectiveTo test for interactions between APOE ε4 genotype and lifestyle factors on worse cognitive abilities in UK Biobank.MethodsUsing UK Biobank cohort data, we tested for interactions between APOE ε4 allele presence, lifestyle factors of alcohol intake, smoking, total physical activity and obesity, and sex, on cognitive tests of reasoning, information processing speed, and executive function (n range = 70,988–324,725 depending on the test). We statistically adjusted for potential confounders of age, sex, deprivation, cardiometabolic conditions, and educational attainment.ResultsThere were significant associations between APOE ε4 and worse cognitive abilities, independent of potential confounders, and between lifestyle risk factors and worse cognitive abilities; however, there were no interactions at multiple correction-adjusted p < 0.05, against our hypotheses.ConclusionsOur results do not provide support for the idea that ε4 genotype increases vulnerability to the negative effects of lifestyle risk factors on cognitive ability, but rather support a primarily outright association between APOE ε4 genotype and worse cognitive ability.

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confidence: 99%

Assessing for interaction betweenAPOEε4, sex, and lifestyle on cognitive abilities

Lyall¹,

Celis‐Morales²,

Graham³

et al. 2019

Neurology

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“…Other studies noted a cognitive gain for APOE e4‐allele carriers through intellectual lifestyle activities. For instance, Rodriguez et al 22 found associations between higher occupational attainment and better cognitive functioning. Wirth et al 23 and Arenaza‐Urquijo et al 24 observed a lower amount of Alzheimer pathology in APOE e4 carriers if they had higher lifetime cognitive activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of APOE e4‐allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

Rodriguez

Röhr

Pabst

et al. 2020

Int J Geriat Psychiatry

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Objectives: Previous studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life. Methods/Design: The population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n = 2 154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination.

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“…And this method (Single nucleotide polymorphisms (SNPs) at nucleotides 112 and 158 of the gene were amplified by PCR using Taq DNA polymerase and a thermal profile were optimized for the locus. By identifying the alleles present at the 112 and 158 polymorphisms, APOE genotype was defined) had been described by Donohoe et al33 According to the methods previously described,34 these 228 subjects were divided into three groups, e2 (ε2/ε2 and ε2/ε3, n=35), e3 (ε3/ε3, n=152), and e4 (ε2/ε4, ε3/ε4, and ε4/ε4, n=41).35 And Table 2 lists the information about the gene distribution in detail.…”

Section: Methodsmentioning

confidence: 99%

<p>Short-term adverse effects of the apolipoprotein E ϵ4 allele over language function and executive function in healthy older adults</p>

Li¹,

Qiu²,

Sun³

et al. 2019

NDT

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Background: The 4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for cognitive impairment. How APOE ε polymorphism affects the language and executive functions of healthy aging subjects remains less clear. Purpose: In this follow-up study, the relationship between APOE status and cognitive performance across various cognitive domains in healthy individuals (without dementia or mild cognitive impairment (MCI)) over 60 years old was investigated. Patients and methods: Based on multiplex amplification refractory mutation system polymerase chain reaction (PCR), 228 subjects (n=228; mean age: 70.59±8.07 years old; male %=40.8%) were divided into three groups, e2 (ε2/ε2 and ε2/ε3, n=35), e3 (ε3/ε3, n=152), and e4 (ε2/ε4, ε3/ε4, and ε4/ε4, n=41). Results: There was no statistical difference ( p >0.05) in the general demographic data and neuropsychological tests among the three groups on the baseline; however, e4 group showed a greater drop rate ( p <0.05) versus non-carriers on verbal fluency (e2: −0.043±0.221; e3: -0.081±0.239; e4: 0.069±0.329) and Webster picture completion (e2: 0.055±0.281; e3: 0.083±0.428; e4: 0.438±1.280) over the subsequent one year. Conclusion: The findings suggest that possession of the APOE ε 4 allele predicted a higher decline on tasks of language function and executive function in healthy elderly. And further research is required to determine whether strengthening the training of language function and executive function will delay the occurrence of cognitive impairment.

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APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-Adult-study.

Cited by 14 publications

References 53 publications

Assessing for interaction betweenAPOEε4, sex, and lifestyle on cognitive abilities

Assessing for interaction betweenAPOEε4, sex, and lifestyle on cognitive abilities

Effects of APOE e4‐allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

<p>Short-term adverse effects of the apolipoprotein E ϵ4 allele over language function and executive function in healthy older adults</p>

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