APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
Kristine M. Tran,
Nellie Kwang,
Angela Gomez-Arboledas
et al.
Abstract:BackgroundApolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer’s Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects.MethodsWe introduced the R136S variant into mouseApoe(ApoeCh) and investigated its effect on the development of AD-related pathology using the 5xFAD… Show more
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