Apocrine Carcinoma In Situ of Sweat Duct Origin

Weinreb, Ilan; Bergfeld, Wilma F.; Patel, Rajiv M.; Ghazarian, Danny

doi:10.1097/pas.0b013e3181839aad

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…In all the cases but one (case n. 8), at least one myoepithelial marker (p63, p40, CK5/6, SOX‐10) was expressed. These findings contribute to suggest that a subgroup of apocrine carcinomas may represent a progression from an in situ carcinoma . Alternatively, the exclusive presence of an invasive component leads to suggest either that an in situ carcinoma has been overgrown by the invasive tumour or that the whole neoplasm has arisen de novo .…”

Section: Discussionmentioning

confidence: 86%

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

Portelli

Projetto

Gori³

et al. 2019

Aust J Dermatology

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Background/Objectives: Primary cutaneous apocrine carcinoma is a rare malignant adnexal skin tumour that can recur locally, spread to regional lymph nodes and metastatize to visceral organs. Wide dissemination and death from disease are much less common. The axilla is the most common site of presentation. It is infrequently reported in the head and neck region.Methods: All cases diagnosed as primary cutaneous apocrine carcinoma of the head and neck were retrospectively collected from the archives of the Division of Pathological Anatomy, University of Florence from 1996 to 2016. There was no history or clinical evidence of breast cancer. Clinical data and followup were collected by the clinicians.Results: Nine cases were found, with a mean age of 76 years, ranging in size between 0.3 and 3.5 cm. Clinically, they were frequently mistaken for basal cell carcinomas. Histopathologically, all the tumours showed decapitation secretion, a tubular, solid or mixed (tubulo-papillary and solid-tubular) growth pattern and were predominantly classified as grade 2 tumours. GCDFP-15 and hormone receptors were variably expressed. HER2 and podoplanin were negative in all cases.In one case, spreading to regional lymph nodes was observed. No cases were associated with death due to the disease. Conclusion:As immunohistochemical analysis lacks specificity in distinguishing primary cutaneous apocrine carcinoma from a cutaneous metastasis of breast carcinoma, detailed clinical history, breast examination, adequate treatment and follow-up are necessary to confirm a diagnosis of primary cutaneous apocrine carcinoma.

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Section: Discussionmentioning

confidence: 86%

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

Portelli

Projetto

Gori³

et al. 2019

Aust J Dermatology

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“…Since the introduction of the concept of carcinoma in situ in 1932 [1], although rare cases of adenocarcinoma in situ of the skin have been reported [2–6], adenocarcinoma in situ of the skin as a concept and as a diagnostic category has not been established [7–9]. Conceptually cases of adenocarcinoma in situ of skin must exist.…”

Section: Discussionmentioning

confidence: 99%

“…When the term carcinoma used unmodified, it generally refers to invasive carcinoma. However, since the introduction of the concept of carcinoma in situ by Broder in 1932 [1], there have been only occasional case reports of adenocarcinoma in situ of skin in the literature [2–6]. Adenocarcinoma in situ of skin as a concept and as a diagnostic category has not been established in the field of dermatopathology [7–9].…”

Section: Introductionmentioning

confidence: 99%

Papillary adenocarcinoma in situ of the skin: report of four cases

Chen

Asgari

2014

Dermatol Pract Concept

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Although rare isolated cases of adenocarcinoma in situ of skin have been reported in the literature, adenocarcinoma in situ of skin as a concept and as a diagnostic category has not been established in the field of dermatopathology. In this work, four cases of papillary adenocarcinoma in situ of the skin are presented. In addition, the notion that lesions previously reported in the medical literature under the term of “papillary eccrine adenoma” are actually adenocarcinoma in situ is discussed.

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“…These lesions occur primarily in the axilla, but can also occur elsewhere on the skin [1, 2, 3 9]. The disease is diagnosed in the fifth to seventh decade of life.…”

Section: Discussionmentioning

confidence: 99%

“…Primary cutaneous apocrine gland carcinoma, a subtype of sweat gland carcinoma, is an extremely rare malignant neoplasm [1, 2, 3]. Most of these neoplasms involve the axilla, but lesions can also occur elsewhere on the skin.…”

Section: Introductionmentioning

confidence: 99%

Primary Cutaneous Apocrine Carcinoma of Sweat Glands:A Rare Case Report

et al. 2011

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Cutaneous apocrine gland carcinoma, a subtype of sweat gland carcinoma, is a very rare malignancy, and only few cases have been reported in the literature. Many of these carcinomas are indolent and slowly developing, but some are rapidly progressive. The treatment of choice is wide local excision with clear margins, with or without lymph node dissection. We report a case of a 67-year-old man who came to our hospital with an ulcerated nodule in the right axilla measuring 1 × 0.8 cm. Histological evaluation showed features of an apocrine gland carcinoma arising in an area of high apocrine gland density.

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Apocrine Carcinoma In Situ of Sweat Duct Origin

Cited by 7 publications

References 5 publications

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

Papillary adenocarcinoma in situ of the skin: report of four cases

Primary Cutaneous Apocrine Carcinoma of Sweat Glands:A Rare Case Report

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