ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease

Jaime, Sánchez-Cuén; Aguilar‐Medina, Maribel; Arámbula-Meraz, Eliakym; José, Romero-Navarro; Granados, Julio; Laura, Sicairos-Medina; Ramos‐Payán, Rosalío

doi:10.3748/wjg.v16.i37.4685

Cited by 26 publications

(16 citation statements)

References 43 publications

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“…Therefore, 10 studies met the inclusion criteria and included in the meta-analysis. Among these studies, 3 studies investigated the XbaI and EcoRI polymorphisms [24], [26], [32], 3 studies investigated the XbaI and ID polymorphisms [33], [34], [35], while the remaining 4 studies only investigated the XbaI polymorphism [23], [25], [36], [37]. Thus, 10, 3, and 3 studies were finally included in the analyses of the association between the ApoB-100 XbaI, EcoRI, ID polymorphisms and the risks of GS, respectively.…”

Section: Resultsmentioning

confidence: 99%

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

et al. 2013

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BackgroundGallstones (GS) is the major manifestation of gallbladder disease, and is the most common risk factor for gallbladder cancer (GBC). Previous studies investigating the association between ApoB-100 gene polymorphisms and the risks of GS and GBC have yielded conflicting results. Therefore, we performed a meta-analysis to clarify the effects of ApoB-100 gene polymorphisms on the risks of GS and GBC.MethodsA computerized literature search was conducted to identify the relevant studies from PubMed and Embase. Fixed or random effects model was selected based on heterogeneity test. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.ResultsA total of 10, 3, and 3 studies were included in the analyses of the association between ApoB-100 XbaI, EcoRI, or insertion/deletion (ID) polymorphisms and the GS risks, respectively, while 3 studies were included in the analysis for the association between XbaI polymorphism and GBC risk. The combined results showed a significant association in Chinese (X+ vs. X−, OR = 2.37, 95%CI 1.52–3.70; X+X+/X+X- vs. X+X+, OR = 2.47, 95%CI 1.55–3.92), but not in Indians or Caucasians. Null association was observed between EcoRI or ID polymorphisms and GS risks. With regard to the association between XbaI polymorphism and GBC risk, a significant association was detected when GBC patients were compared with healthy persons and when GBC patients were compared with GS patients. A significant association was still detected when GBC patients (with GS) were compared with the GS patients (X+X+ vs. X-X−, OR = 0.33, 95%CI 0.12–0.90).ConclusionThe results of this meta-analysis suggest that the ApoB-100 X+ allele might be associated with increased risk of GS in Chinese but not in other populations, while the ApoB-100 X+X+ genotype might be associated with reduced risk of GBC. Further studies with larger sample sizes are needed to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

et al. 2013

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“…[11] reported that X(+) allele of APOB gene is a risk factor for the development of gallstone in Chinese patients, in another study no association exists between the APOB XbaI polymorphism and cholelithiasis in Mexican population. [12] Saha et al . [10] observed a significant association of APOB XbaI gene polymorphism with obesity and serum lipid levels while contradictory results also available, Misra et al .…”

Section: Introductionmentioning

confidence: 99%

Association of apolipoprotein B XbaI gene polymorphism and lipid profile in northern Indian obese

Srivastava¹,

Prakash²,

Srivastava³

et al. 2013

Indian J Hum Genet

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BACKGROUND:Over the last few decades, obesity, diabetes, and hypertension have become main health evils. The health problems of obesity are well-recognized. However, the fact that all obese individuals are not at the same risk of developing a disease is also recognized. The apolipoprotein B (APOB) plays a central role in lipid metabolism. So we compare the association of APOB XbaI gene polymorphism and lipid profile total in obese north Indian population.MATERIALS AND METHODS:A total of 132 obese (body mass index [BMI] >25 kg/m2) and 132 age matched non-obese (BMI ≤ 25 kg/m2) subjects were studied after taking detailed clinical profile. Lipid profile in serum/plasma was done using commercial kits. Genetic analysis of APOB XbaI was done using Polymerase Chain Reaction-Restriction Fragment Leanth polymorphism (PCR-RFLP).STATISTICAL ANALYSIS:Statistical analysis was performed by Statistical Package for the Social Sciences (SPSS) (version 11.5) software (IBM Corporation). All continuous variables were expressed as mean ± SD and tested by analysis of variance test. Comparisons of categorical variables were assessed using χ2 tests or Fisher's exact test. P < 0.05 was considered as significant.RESULTS:Analysis showed that obese subjects had significantly higher value of the waist-to-hip ratio, blood pressure (systolic and diastolic), and lipid profile. In APOB XbaI gene polymorphism, we did not find significant differences in genotype or allele frequencies. Moreover, none of the studied metabolic parameters (lipid profile) showed any association with the gene polymorphism.CONCLUSIONS:Study reveals no considerable association of APOB XbaI gene polymorphism with obesity and lipid profile in north Indians.

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“…The literature search identified 16 potentially relevant papers. Seven papers were excluded and 9 papers (5 in English [ 5 , 11 , 12 , 20 , 21 ], 4 in Chinese [ 22 – 25 ]) were included finally. A flow diagram of the study selection process is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The present study was approved by the Ethics Committee of the Ruijin Hospital, Shanghai JiaoTong University School of Medicine. Five of the eligible studies including 830 gallbadder stone disease patients and 882 controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD [ 5 , 11 , 12 , 21 , 23 ]. Four of the eligible studies including 802 cases and 691 controls were used to assess the association between CYP7A1 -204A > C polymorphism and serum lipid levels [ 20 , 22 , 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis

et al. 2014

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BackgroundThe CYP7A1 gene polymorphism has been reported to be associated with gallbladder stone disease (GSD) and serum lipid levels, but the results were inconsistent. This meta-analysis aimed to evaluate the influence of the -204A > C polymorphism in the promoter of CYP7A1 gene on the GSD and serum lipid levels.MethodsAccording to inclusion/exclusion criteria, eligible studies on CYP7A1 gene -204A > C polymorphism of serum lipid levels and the risk of GSD were retrieved. Depending on the between-study heterogeneity, the fixed- or random-effects model was applied, and the data were analyzed using the RevMan software (V5.2).ResultsFive studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1 -204A > C polymorphism with GSD. Overall comparison of alleles A with C in all study population yielded 5% but non-significant increased risk of GSD (OR = 1.05, 95% CI: 0.91 − 1.22, P = 0.48). Subgroup analysis by ethnic differences did not show any association between CYP7A1 -204A > C polymorphism and GSD either. Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1 -204A > C polymorphism with serum lipid levels. All the subjects were from the Asian population. The pooled effects indicated that AC genotype had higher levels of TG than AA (MD = -0.42, 95% CI: -0.76 − -0.08, P = 0.01). CC genotype in cases had higher levels of TC (MD = 0.65, 95% CI: 0.25 − 1.05, P = 0.001) and LDL-C (MD = 0.40, 95% CI: 0.06 − 0.73, P = 0.02) than AA, AA (MD = -0.35, 95% CI: -0.60 − -0.10, P = 0.007) and AC (MD = −0.35, 95% CI: -0.61 − -0.08, P = 0.01) genotypes in controls had higher levels of TC than CC, and AA genotype in controls had higher levels of HDL-C than CC (MD = -0.15, 95% CI: -0.21 − -0.09, P < 0.00001).ConclusionsThe CYP7A1 -204A > C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease.Electronic supplementary materialThe online version of this article (doi:10.1186/1476-511X-13-126) contains supplementary material, which is available to authorized users.

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ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease

Abstract: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population.

Cited by 26 publications

References 43 publications

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

Association of apolipoprotein B XbaI gene polymorphism and lipid profile in northern Indian obese

Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis

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