Apo E gene polymorphism in patients with metabolic syndrome and cognitive disorders

Зуева, Ирина Борисовна; Ulitina, Anna; Гораб, Д. Н.; Москаленко, М. В.; Дубина, М. В.

doi:10.18705/1607-419x-2012-18-5-421-428

Cited by 2 publications

(3 citation statements)

References 63 publications

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“…The ε3 allele was observed in 77.8% of individuals, the ε4 allele in 13.2% and the ε2 allele in 9%. Our data are in agreement with the results of researchers from around the world [ 12 , 14 , 15 ] as well as from domestic researchers [ 4 , 35 ]. For example, 70.4% had the ε3/ε3 genotype, 9% had the ε3/ε4 genotype, and 6% had the ε2/ε3 genotype, according to I.B.…”

Section: Discussionsupporting

confidence: 92%

“…High levels of depression were observed 1.9 times more frequently in carriers of the ε4 allele than in those with no depression and 1.28 times more frequently than in those with moderate levels of depression. Our data are consistent with both the results of domestic researchers, who concluded that carrying the ε4 allele of the APOE gene is an unfavorable factor contributing to the development of depression [ 35 ], and the results of a large-scale meta-analysis conducted by W.W. Wang, et al 2019 [ 36 ]. The meta-analysis was a review of 398 sources of information on the association between the ε4 allele of the APOE gene and depression.…”

Section: Discussionsupporting

confidence: 92%

“…For example, 70.4% had the ε3/ε3 genotype, 9% had the ε3/ε4 genotype, and 6% had the ε2/ε3 genotype, according to I.B. Zueva et al, 2012 [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of the APOE Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program

Gafarov,

Gromova,

Shakhtshneider

et al. 2023

JPM

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The APOE gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the APOE gene polymorphism with depression in the white adult population aged 25–64 years in Novosibirsk (Western Siberia). The third screening of the WHO program “MONICA-psychosocial” was conducted in 1994–1995. In total, 403 men (the average age was 34 ± 0.4 years, the response was 71%) and 531 women (the average age was 35 ± 0.4 years, the response was 72%) of the open population of residents aged 25–64 years of the Oktyabrsky district of Novosibirsk were examined. The “MONICA-MOPSY” psychosocial questionnaire was used to assess depression. A high level of depression was found in 12.8% of the population: in 8.9% of men and in 15.8% of women. The frequencies of APOE gene polymorphism genotypes ε2/3, ε2/4, ε3/3, ε3/4, and ε4/4 were 14.9%, 3.1%, 61.6%, 17.5%, and 2.9%, respectively. Carrying the ε3/4 genotype of the APOE gene increased the odds of developing major depression by 2.167 times (95% CI 1.100–4.266) compared to carrying the ε3/3 genotype of the APOE gene in people without depression (χ2 = 5.120 df = 1 p = 0.024). Carriers of the ε4 allele were 2.089 times (95% CI 1.160–3.761) more likely to have a high level of depression than those without this allele and no depression (χ2 = 6.148 df = 1 p = 0.013), and 2.049 times (95% CI 1.117–3.758) more likely to have a moderate level of depression than those without this allele (χ2 = 5.470 df = 1 p < 0.019). The ε4 allele of the APOE gene is associated with a high level of depression.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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Association of the APOE Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program

Gafarov,

Gromova,

Shakhtshneider

et al. 2023

JPM

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Молекулярно-генетические маркеры (ген <I>APOE</I>) и депрессия среди лиц 25–64 лет (международная программа ВОЗ «MONICA-PSYCHOSOCIAL»)

Гафаров,

Громова,

Шахтшнейдер

et al. 2023

Атеросклероз

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Введение. В настоящее время распространенность депрессии составляет 3–5 %, на нее приходится второе по величине экономическое бремя болезней [1–3]. Ген аполипопротеин Е (АРОЕ) включает три аллеля: ε2, ε3 и ε4, которые могут вызывать предрасположенность к депрессии. Некоторые исследователи сообщают, что полиморфизмы гена АРОЕ являются факторами риска возникновения депрессии [4]. Аллели APOE ε2, ε3 и ε4 могут объединяться, образуя шесть генотипов (гомозиготы по ε2, ε3 и ε4; гетерозиготы по ε2/3, ε2/4 и ε3/4). Частоты аллелей и генотипов различались среди разных этнических групп и географических районов [5–7]. Низкая концентрация холестерина в сыворотке связана с риском депрессии [8, 9]. У многих пациентов с депрессией наблюдается потеря нейронов и структурные аномалии головного мозга, которые могут быть результатом дислипидемии [10]. У пациентов с депрессией была более высокая частота аллеля АРОЕ ε4, полиморфизм АРОЕ ε4 был фактором риска депрессии [11]. По сравнению с пациентами, у которых не было аллеля ε4, у пациентов с аллелем ε4 проявлялись более выраженные симптомы депрессии [12, 13]. Таким образом, учитывая вышеизложенные факты, целью нашего исследования стало изучение связи генотипов гена APOE с депрессией среди лиц 25–64 лет г. Новосибирска.

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Apo E gene polymorphism in patients with metabolic syndrome and cognitive disorders

Cited by 2 publications

References 63 publications

Association of the APOE Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program

Association of the APOE Gene Polymorphism with Depression in White Adults in the WHO “MONICA-Psychosocial” Program

Молекулярно-генетические маркеры (ген <I>APOE</I>) и депрессия среди лиц 25–64 лет (международная программа ВОЗ «MONICA-PSYCHOSOCIAL»)

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