Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy.

Nashef, Lina; Walker, Frederic B.; Allen, Peter; Sander, Josemir W.; Shorvon, Simon; Fish, D. R.

doi:10.1136/jnnp.60.3.297

Cited by 345 publications

(291 citation statements)

References 27 publications

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“…When ictal cardiorespiratory variables were recorded in people with epilepsy, an increase in heart rate in 91% of 41 seizures and a transient bradycardia in 5 seizures (4 patients) were found (Nashef et al 1996). Another study evaluated the eletrocardiographic (ECG) changes during 51 seizures in 43 patients with refractory epilepsy (Nei et al 2000).…”

Section: Cardiac Abnormalities and Sudepmentioning

confidence: 99%

The pilocarpine model of epilepsy: what have we learned?

Scorza

Arida

Naffah-Mazzacoratti

et al. 2009

An. Acad. Bras. Ciênc.

155

103

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The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.

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Section: Cardiac Abnormalities and Sudepmentioning

confidence: 99%

The pilocarpine model of epilepsy: what have we learned?

Scorza

Arida

Naffah-Mazzacoratti

et al. 2009

An. Acad. Bras. Ciênc.

155

103

View full text Add to dashboard Cite

show abstract

“…when ictal cardiorespiratory variables were recorded in people with epilepsy, an increase in heart rate in 91% of 41 seizures and a transient bradycardia in five seizures (four patients) were found 38 . Another study evaluated the eletrocardiographic (ECG) changes during 51 seizures in 43 patients with refractory epilepsy 39 .…”

Section: Sudden Unexpected Death In Epilepsymentioning

confidence: 97%

The mistery of Gustave Flaubert's death: could sudden unexpected death in epilepsy be part of the context?

Albuquerque

Scorza

Arida

et al. 2009

Arq. Neuro-Psiquiatr.

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-Epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role. More than two decades ago, temporal lobe epilepsy was suggested as having been the ''nervous disease'' of Gustave Flaubert, one of the most important French novelists. In these lines, as the circumstances of his death were the subject of fabulous and mysterious speculations, we postulated in this paper that Falubert's death could be due SUDEP phenomenon.KEy worDS: epilepsy, Gustave Flaubert, SUDEP, seizure. O mistério da morte de Gustave Flaubert: pode a morte súbita em epilepsia fazer parte o contexto ?Resumo -A epilepsia é a condição neurológica crônica grave mais comum e a morte súbita em epilepsia (SUDEP) é a mais importante causa de morte diretamente relacionada à epilepsia. Informações sobre fatores de risco para SUDEP são conflitantes, porém, a alta freqüência de crises epilépticas é um fator de risco em potencial. Além disso, os mecanismos causais para SUDEP ainda não estão conhecidos, mas é muito provável que arritmias cardíacas durante e entre as crises epilépticas ou a transmissão da atividade epiléptica para o coração via sistema nervoso autônomo desempenhem um importante papel. Mais de duas décadas atrás, foi proposto que a "doença nervosa" de Gustave Flaubert, um dos mais importantes novelistas franceses, era epilepsia do lobo temporal. Nesse sentido, como a morte de Gustave Flaubert ainda seja motivo de misteriosa especulação, nosso artigo propõe que a mesma poderia estar relacionada ao fenômeno de SUDEP.

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“…19 In addition, central or mixed apnea accompanied by bradycardia has also been suggested to cause hypoxia in patients with seizures. 20 Convulsions also have direct effects on autonomic, cardiovascular and respiratory functions. Cardiovascular dysfunction, pulmonary edema, and postictal depression of autonomic respiratory reflexes and cardiovascular function may contribute to hypoxia.…”

Section: Discussionmentioning

confidence: 99%

“…10 Therefore, a biomarker that demonstrates the kidney injury in an earlier stage has been sought, and NGAL, NAG, and L-FABP have been demonstrated to reflect the renal damage in the early period. [19][20][21][22][23][24][25][26][27][28][29] NGAL, one of the members of lipocalin family with a 25 kDa molecular weight, is a protein in the small glycoprotein structure. It is released from renal tubular cells, hepatocytes, and endothelial cells as a response to cellular stress in certain conditions, such as ischemia and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Urinary kidney injury molecules in children with febrile seizures

et al. 2016

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Objective: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-b-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. Methods: The study included 28 children with FS and 34 age and gender matched healthy children. Serum biochemistry and blood gases were measured in the serum samples. Estimated glomerular filtration rate (eGFR) was calculated. NGAL, NAG, L-FABP, and creatinine (Cr) were measured in the urine samples. The ratios of kidney injury markers to urinary Cr were used for comparisons.Results: There were no significant differences in eGFR and serum chemistry values between the FS and the control group (p > 0.05). Hypoxia was detected in 67.9% of the FS patients. The FS group had significantly higher urinary kidney injury molecules to Cr ratios compared to the controls, including NGAL/Cr (17.9 ± 9.8; 6.7 ± 4.0, respectively; p < 0.001), NAG/Cr (0.55 ± 0.29; 0.21 ± 0.16, p < 0.001), and L-FABP/Cr (4.85 ± 2.93; 1.74 ± 1.16, p < 0.001). Conclusion: Increased urinary NGAL/Cr, NAG/Cr, and L-FABP/Cr values, in patients with FS compared to healthy controls, suggest a possible subclinical renal damage in these patients. ARTICLE HISTORY

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Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy.

Cited by 345 publications

References 27 publications

The pilocarpine model of epilepsy: what have we learned?

The pilocarpine model of epilepsy: what have we learned?

The mistery of Gustave Flaubert's death: could sudden unexpected death in epilepsy be part of the context?

Urinary kidney injury molecules in children with febrile seizures

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