Apneic response to fentanyl in adult rats: Role of laryngeal afferents
Jianguo Zhuang,
Xiuping Gao,
Shan Shi
et al.
Abstract:Intravenous (systemic) bolus injection of fentanyl (FNT) reportedly induces an immediate vagal‐mediated apnea; however, the precise origin of vagal afferents responsible for this apnea remains unknown. We tested whether intralaryngeal (local) application of FNT would also trigger an apnea and whether the apneic response to both local and systemic administration of FNT was laryngeal afferent‐mediated. Cardiorespiratory responses to FNT were recorded in anesthetized male adult rats with and without bilateral sec… Show more
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