Apnea Oxygenation Test Safety and Accesibility With the Perftoran Solution

Колсанов, А В; Mironov, A. A.; Neljubina, N. E.; Yaremin, B. I.

doi:10.1097/00007890-201007272-01091

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another method that has not gained wide use and is majorly limited by regulations and availability describes the use of artificial oxygen transporting solutions, such as perfluorocarbon-based oxygen carriers. In a study from Russia, the use of intravenous Perftoran (a solution of perfluordecaline and perfluormethylcyclohexylpiperidine 2:1 in emulsion) increased the pre-apnea and apnea-PaO 2 compared to controls without affecting the PaCO 2 levels [29].…”

Section: Augmentation Of Oxygenationmentioning

confidence: 98%

“…The authors argue that the prior literature suggests that only 30-60 s are needed to confirm apnea. Furthermore, they discuss that a slower increase in PaCO 2 compared to conventional AT does Oxygen transporting solutions Increase of pre-apnea and apnea-PaO 2 Kolsanov et al [29] not result in CSF pH equilibrium based on animal data, indicating that if the hypoventilation process lasts less than 60 min, the CSF pH will not have enough time to equilibrate [24]. A combination of these two methods has also been described in 60 patients undergoing AT with CO 2 augmentation, without disconnecting from the ventilator and with monitoring the end-tidal PCO 2 .…”

Section: Carbon Dioxide Augmentation and Elevation Of Co 2 Level Priomentioning

confidence: 99%

See 1 more Smart Citation

Apnea Testing for the Determination of Brain Death: A Systematic Scoping Review

2020

View full text Add to dashboard Cite

Apnea is one of the three cardinal findings in brain death (BD). Apnea testing (AT) is physiologically and practically complex. We sought to review described modifications of AT, safety and complication rates, monitoring techniques, performance of AT on extracorporeal membrane oxygenation (ECMO), and other relevant considerations regarding AT. We conducted a systematic scoping review to answer these questions by searching the literature on AT in English language available in PubMed or EMBASE since 1980. Pediatric or animal studies were excluded. A total of 87 articles matched our inclusion criteria and were qualitatively synthesized in this review. A large body of the literature on AT since its inception addresses a variety of modifications, monitoring techniques, complication rates, ways to perform AT on ECMO, and other considerations such as variability in protocols, lack of uniform awareness, and legal considerations. Only some modifications are widely used, especially methods to maintain oxygenation, and most are not standardized or endorsed by brain death guidelines. Future updates to AT protocols and strive for unification of such protocols are desirable.

show abstract

Section: Augmentation Of Oxygenationmentioning

confidence: 98%

Section: Carbon Dioxide Augmentation and Elevation Of Co 2 Level Priomentioning

confidence: 99%