Aplicación de las pruebas electrofisiológicas en el estudio de enfermedades neurológicas con afectación visual

Rodríguez-Mena, Diego; Almárcegui, Carmen; Dolz, Isabel; Júlvez, Luis Pablo; García‐Martín, Elena

doi:10.1016/j.oftal.2012.09.001

Cited by 1 publication

(2 citation statements)

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“…When comparing AD patients and healthy controls, a significant NFL reduction has been observed in AD patients, more prominent in the inferior [ 172 , 173 ] and superior quadrants [ 140 , 174 ]. A meta-analysis including 887 AD patients and 864 controls evidenced peripapillary NFL thinning in the superior and inferior quadrants of the retina in AD patients that was not present in controls [ 175 ]. Additionally, AD patients had reduced thickness in GCL, NFL, IPL, and outer nuclear layer (ONL) compared with controls [ 176 ].…”

Section: Paraclinical Visual Studies In Admentioning

confidence: 99%

“…VEP extracts signals directly from the visual cortex, which are dependent on adequate integrity of the visual system (eye, retina, optic nerve, and visual cortex). In patients with AD, decreased amplitude of P2 or P100 components are observed at 100 ms [ 45 , 46 , 48 , 96 , 138 – 140 , 175 , 184 – 186 ]. Yet, other studies have shown no changes in pattern-VEP nor association with NFL thinning [ 187 ] in the peripapillary or macular regions [ 188 ].…”

Section: Paraclinical Visual Studies In Admentioning

confidence: 99%

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Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview

et al. 2018

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Alzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises patients' daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by Aβ, tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives.

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