This study aimed to evaluate the deposition of NaCl nanoparticles during filtration in a cellulose filter medium (HEPA). The diameter of the generated polydisperse particles was between 6 and 800nm. Deposition was evaluated with the curves of pressure drop as a function of time. The permeability of the filter medium was determined and, after the deposition of particles, specific resistance of the formed cake was obtained. Filter performance was evaluated by counting particles before and after the filter medium and the pressure drop was monitored in order to obtain the filtration curve. Filtration velocity was kept at 0.06 m/s, and the concentration of the solution generated at a rate of 0.0042 L /min in a commercial inhaler was of 5 g/L. The results showed that this filter showed two steps during the deposition of particles, an internal filtration stage and a surface filtration stage. Although this filter is highly efficient in removing particles in the range evaluated, roughly 100%, particle penetration was observed in the range between 50 and 200nm.