Aplastic Anemia Following Hepatitis Associated With Human Herpesvirus 6

Features of Hepatitis in Hepatitis‐associated Aplastic Anemia

“…The etiology of hepatitis in those with HAA remains largely unknown. Isolated case reports have suggested an association between HAA and hepatitis viruses (16), parvovirus B19 (17–19), HHV‐6 (13), and transfusion transmitted virus (20). A possible hepatitis virus (A and B) etiology for HAA was suggested and identified in <6% patients with HAA in 2 studies involving 214 and 36 patients, respectively (1,3), whereas hepatotropic viruses, along with parvovirus B19, were not identified in other large HAA studies (5,12).…”

“…Studies on HAA have been mainly focused on the clinical course and overall management of the hematologic features of this entity (3,5,6). Clinical presentation, laboratory findings, and histopathologic features of the preceding hepatitis are rarely addressed in isolated case reports (13,14) and small series (15). This is a retrospective study of patients with HAA to describe the above-mentioned parameters, including immunophenotypic features of the inflammatory cells.…”

Epstein Barr Virus Infection Affects Function of Cytotoxic T Lymphocytes in Patients with Severe Aplastic Anemia

“…Genetics may also play a role in the pathogenesis of SAA. Studies have even considered the participation of some environmental factors (damage induced by chemicals, drugs, viruses, or antigens) in the pathogenesis of SAA by activating lymphocytes or other immune responses, especially viral infection, which has attracted considerable recent attention from scholars [17–20]. …”

Keeping it in the family: Three relatives with HbSC disease and simultaneous acute pulmonary emboli

“…All six were originally from Jamaica, had SCD with worsening anemia and evidence of bone marrow erythroid hypoplasia [4]. Other viruses recognized to be associated with red cell aplasia, although not specifically in SCD, include Epstein Barr, mumps, hepatitis, and Human Herpes virus 6 [5, 6].…”