Aplastic anaemia in the northern region of England

Tweddle, DA; Reid, M M

doi:10.1111/j.1651-2227.1996.tb13938.x

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…3) [1][2][3][4][5] but is similar to the reports from Asia: 4.8 in Malaysia [21], 5.7 in Taiwan [9], and 7.5 in China [8,22]. The current study demonstrated a remarkable agerelated distribution with steeply increased incidence after the age of 50 (6.2 per million) with a peak incidence at the age over 80 years old (14.3 per million).…”

Section: Discussionsupporting

confidence: 88%

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Adult aplastic anemia in Thailand: incidence and treatment outcome from a prospective nationwide population-based study

et al. 2021

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The incidence and outcomes of aplastic anemia (AA) in Asia remain limited. This study aimed to explore the incidence and outcomes of patients with adult AA across the country of Thailand. This is a prospective multi-center nationwide population-based observational study of AA patients aged at least 15 years old, diagnosed from August 2014 to July 2016, with a longitudinal follow-up period over 2 years. There were 348 newly diagnosed adult AA patients during the enrollment period, giving an annual incidence of 4.6 per million. The incidence of severe (SAA) and very severe aplastic anemia (VSAA) (3.8 per million) was higher than non-severe AA (NSAA, 0.8 per million). The peak incidence was observed in the patients aged from 80 to 89 years old (14.4 per million). The 2-year overall survival (OS) in NSAA, SAA, and VSAA were 65.5%, 49.3%, and 20.1%, respectively (P < 0.001). With regard to the response to immunosuppressive therapy, the overall response rate (ORR) in SAA/VSAA treated with rabbit anti-thymocyte globulin with/without cyclosporin A (rATG ± CsA) were significantly superior to those treated with CsA alone, or anabolic steroids (44.4% vs 36.4% and 31.2%, respectively, P < 0.001). The 2-year OS in SAA/VSAA treated with rATG ± CsA, CsA, and anabolic steroids were 54.8%, 54.5%, and 37.6% (P = 0.037), respectively. The incidence of adult AA in Thailand is higher than those in Western countries, and the peak incidence is in the elderly. rATG ± CsA provided a better response than anabolic steroids, translating to the superior survival in SAA/VSAA treated with rATG ± CsA.

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Section: Discussionsupporting

confidence: 88%

“…The incidence of aplastic anemia (AA) varied worldwide. The estimated annual incidence in Western countries was 1.5-2.3 per million [1][2][3][4][5], while it was 2-3 times higher in Asia (3.0-7.5 per million) [6][7][8][9]. The explanation for these differences is unknown; however, it may be related to genetic or environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Adult aplastic anemia in Thailand: incidence and treatment outcome from a prospective nationwide population-based study

et al. 2021

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“…This was similar to studies in France (May & Guiguet, 1990), which also found slightly higher rates in children, as did the U.K. study. A small childhood case series also computed similar childhood rates in the North of England (Tweddle & Reid, 1996) and Scandinavia (Clausen et al , 1996). Rates in China (Yang & Zhang, 1991) were 3‐fold greater and in Thailand about twice as great (Issaragrisil et al , 1996).…”

Section: Time Trends By Disease Typementioning

confidence: 82%

Time Trends in Incidence of Haematological Malignancies and Related Conditions

Cartwright¹,

Gilman²,

Gurney³

1999

Br J Haematol

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“…Evidence for a higher rate of AA in Asian countries than in the West has come from diverse sources, not all of equal reliability, and [35][36][37] In the first phase of the present study, based on similar methodology to the IAAAS, we determined a stable rate of 3.9 per million for the Bangkok metropolitan area and in Khonkaen, 5 per million. 27 Other Asian series have produced a range of 5 to 7 per million.…”

Section: Discussionmentioning

confidence: 99%

“…Rice was predominant, and the overall relative risk estimate was 0.6 (0.4-1.0; 77 exposed cases, 300 exposed controls), in contrast to the positive association that we observed in phase 1, based on less-detailed information. 35 For cassava, the relative risk was 4.5 (1.8-11; 13 cases, 13 controls). For sugarcane (8 exposed cases, 29 exposed controls; crude relative risk estimate, 1.2), there was no association.…”

Section: Pesticides (Phase 2 Khonkaen)mentioning

confidence: 99%

The epidemiology of aplastic anemia in Thailand

Issaragrisil

Kaufman

Anderson

et al. 2006

Blood

159

113

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Aplastic anemia has been linked to environmental exposures, from chemicals and medical drugs to infectious agents. The disease occurs more frequently in Asia than in the West, with incidence rates 2-to 3-fold higher. We report updated results of an epidemiologic study conducted in Thailand from 1989 to 2002, in which 541 patients and 2261 controls were enrolled. Exposures were determined by in-person interview. We observed significantly elevated relative risk estimates for benzene (3.5) and other solvents (2.0) and for sulfonamides (5.6), thiazides (3.8), and mebendazole (3.0). Chloramphenicol use was infrequent, and no significant association was observed. Agricultural pesticides were implicated in Khonkaen (northeastern Thailand). There were significant associations with organophosphates (2.1), DDT (6.7), and carbamates (7.4). We found significant risks for farmers exposed to ducks and geese (3.7) and a borderline association with animal fertilizer (2.1). There was a significant association in Khonkaen with drinking other than bottled or distilled water (2.8).

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Aplastic anaemia in the northern region of England

Cited by 7 publications

References 4 publications

Adult aplastic anemia in Thailand: incidence and treatment outcome from a prospective nationwide population-based study

Adult aplastic anemia in Thailand: incidence and treatment outcome from a prospective nationwide population-based study

Time Trends in Incidence of Haematological Malignancies and Related Conditions

The epidemiology of aplastic anemia in Thailand

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