Aplastic Anaemia, Acute Myeloblastic Leukaemia, and Oxymetholone

Delamore, I. W.; Geary, C. G.

doi:10.1136/bmj.2.5764.743

Cited by 47 publications

(13 citation statements)

References 10 publications

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“…However, several reports have indicated that subJects with aplastic anemia associated with various agents have later developed acute leukemia (6,7,13,15,23,41,56). In some cases, the conversion from hypoplastic anemia to leukemia occurred within a r'elatively short period of time (16,23). Although the leukemia is usually ,of the myeloblastic type, acute lymphatic leukemia has also been reported in associatio,n (44).…”

Section: Relation Of Aplastic Anemia To Leukemiamentioning

confidence: 99%

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Infante¹,

Epstein²,

Newton³

1978

Scand J Work Environ Health

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& health 4 (1978) 137-150. In the United States, chlordane and heptachlor are commonly used in pesticide formulations for agricultural purposes and for termite eradication in the home. Pathological conditions possibly associated with prior exposure to such formulations are presented in this report. Five recently diagnosed cases of neuroblastoma associated with chlordane exposure during prenatal and postnatal development have been identified. Three cases of aplastic anemia and three cases of acute leukemia are also reported in association with chlordane formulations. The cases suggesting association between chlordane exposure and neuroblastoma are of interest in view of recent data on the carcinogenicity and mutagenicity of chlordane and heptachlor and in view of data on environmental distributions and body burdens. The cases of aplastic anemia and leukemia are of interest in view of previous literature reports on associations between chlordane and similar chlorinated hydrocarbon pesticides and blood dyscrasias, and in view of reports indicating that some subjects with aplastic anemia convert to leukemia. As previous studies are too limited to allow the development of valid inferences regarding the neoplastic risk of chlordane, there is need for formal epidemiologic study to evaluate health risks associated with chlordane through home exposure and through occupational exposure for termite exterminators, lawn care operators, and for workers in the agricultural setting.

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Section: Relation Of Aplastic Anemia To Leukemiamentioning

confidence: 99%

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Infante¹,

Epstein²,

Newton³

1978

Scand J Work Environ Health

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“…We found evidence of this complication at autopsy in 1 patient. Apart from the re port by Delamore and G eary [8], no data suggesting a 'leukemia-induc ing activity' of androgens in classic aplastic anaemia has been described. The results of our retrospective non-randomized study do not contradict the findings of Williams et al [53], Bock and H eimpel [4], and Gordon Smith et al [13], in failing to show a significant effect on patient survival and stable haematopoietic recovery of high-dose androgen therapy.…”

Section: Discussionmentioning

confidence: 99%

Acquired Aplastic Anaemia in Adults

Hl¹,

Ca²,

Hf³

et al. 1977

Acta Haematol

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The effect of conservative treatment of aplastic anaemia was evaluated retrospectively in 40 patients. No significant beneficial effect was provided by long-term high-dose oxymethalone in 20 patients or by metenolone, adrenostenolone, or testosterone in 14 patients. Splenectomy gave no improvement in the majority of cases, although in some it decreased the transfusion requirement. Immunosuppressive treatment was successful in 1 patient with a positive LE phenomenon. Until a specific treatment becomes available, the possibility offered by alternative treatment, e.g. bone marrow transplantation, in cases with poor prognostic parameters should be considered

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“…Further studies will be necessary before a conclusion can be reached, but the difficulties inherent in finding standardized groups of patients with malignant disease for long-term study are numerous. Also, account has to be taken of the report by Delamore and Geary (1971) that 4 patients with aplastic anaemia developed acute myeloblastic leukaemia after treatment with oxymetholone.…”

Section: Resultsmentioning

confidence: 99%

Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate

Rawbone¹,

Bagshawe²

1972

Br J Cancer

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Summary.-The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these agents have no protective effect on bone marrow suppression during cytotoxic chemotherapy. It was observed that the time interval between the initial nadir total leucocyte count and the return to pre-treatment values in those patients receiving the anabolic steroids was significantly shorter than in the control group.

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Aplastic Anaemia, Acute Myeloblastic Leukaemia, and Oxymetholone

Cited by 47 publications

References 10 publications

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Acquired Aplastic Anaemia in Adults

Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate

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