Aplasia cutis congenita and limb anomaly: A case of non-scalp lesion

Abstract

Aplasia cutis congenita is a rarely seen disease in which dermis, subdermal tissue and extremely rarely bone are absent. Significant number of cases are lost due to infections, electrolyte imbalance, and massive hemorrhage. In this report, we present a 2-day-old infant who had a wide aplasia cutis area on the right lower limb.

The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity due to Intrauterine Varicella Infection

“…About 15% of ACC lesions occur in the trunk and extremities [12] and are generally bilateral and symmetrical. However, asymmetrical distribution has been reported [9].…”

“…Ulceration in newborns can be associated with several conditions, and one of them is ACC [9]. Aplasia cutis congenital is a rare congenital condition [2] in the absence of skin, most often involving the epidermis and dermis [11] and in some cases involve subcutan area [9]; which usually occurs in a localized or wide area, or appears as scar at birth [11]. Cutaneous aplasia can occur as an isolated defect, associated with other developmental abnormalities, or as a description of various abnormalities.…”

“…Conservative treatment for small ACC lesions using petrolatum, silver sulfadiazine or bacitracin aimed to give rise to granulation and healing with scars [2,5]. Shirvany et al reported that ACC repair using mupirocin took about two months, and in cases with no scalp wounds, the healing process took 38 days [4,9]. The use of acellular dermal graft and cultured epithelial autograft has also been reported with full repair in 7 to 14 days [6].…”