2017
DOI: 10.1160/th17-07-0474
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Apixaban Auto-intoxication: Toxicokinetics and Coagulation Tests

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Cited by 6 publications
(11 citation statements)
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“…As previously reported, the apixaban plasma concentration vs. time profile exhibited a multiphasic elimination profile, with an initial rapid decline followed by a more gradual terminal phase [4]. Apixaban was eliminated with a terminal half-life of 8.2 h. The half-life described in adults overdose was between 6 h and 15 h depending on the patient and other co-administered drugs [6][7][8][9]. The rapid elimination may explain the absence of bleeding despite high concentrations.…”
Section: Discussion/conclusionsupporting
confidence: 53%
See 1 more Smart Citation
“…As previously reported, the apixaban plasma concentration vs. time profile exhibited a multiphasic elimination profile, with an initial rapid decline followed by a more gradual terminal phase [4]. Apixaban was eliminated with a terminal half-life of 8.2 h. The half-life described in adults overdose was between 6 h and 15 h depending on the patient and other co-administered drugs [6][7][8][9]. The rapid elimination may explain the absence of bleeding despite high concentrations.…”
Section: Discussion/conclusionsupporting
confidence: 53%
“…Apixaban has linear pharmacokinetics, and concentration-related pharmacodynamic effects have been described in adults [4]. Many clinical cases reported severe self-poisoning with apixaban among adult patients [5][6][7][8][9]. To date, there is no available data about apixaban pharmacokinetics in children, and no intoxication has previously been described.…”
Section: Introductionmentioning
confidence: 99%
“…Another important finding is that anti‐Xa activity seems to be linearly related to concentrations up to 4000 μg l −1 . This is the fourth published case of self‐poisoning with Apixaban , with the highest concentrations reported so far. The apparent half‐life is close to the usual value at therapeutic doses (mean/SD: 11.7 h/3.3) .…”
Section: Discussionmentioning
confidence: 77%
“…34 Finally, a 48-year-old woman who ingested 280 mg apixaban developed minimal bleeding despite a superficial knife cut in her left elbow. 25 Overall, neither plasma DOAC levels nor coagulation parameters correlated well with bleeding. In our series, the observed peak concentrations did not correlate with the presumed ingested dose.…”
Section: Discussionmentioning
confidence: 91%
“…Overall, 29 additional cases mostly involving intentional exposure to dabigatran ( n = 15), rivaroxaban ( n = 8) and apixaban ( n = 6) were published (Table 3). 12–35 Only 10 of these 29 cases presented bleeding. A 53‐year‐old man who co‐ingested 200 mg apixaban presented minor oozing from his femoral venous line insertion site, easily controlled with direct pressure and prothrombin complex concentrate 13 .…”
Section: Discussionmentioning
confidence: 99%