Apitherapy

Farooqui, Tahira; Farooqui, Akhlaq A.

doi:10.1002/9781119155195.ch16

Cited by 6 publications

(6 citation statements)

References 106 publications

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“…In our work, propolis mitigated 6-OHDA-induced loss of TH-positive nigrostriatal dopaminergic neurons. Yet, despite the many variables that can hinder the comparison between different studies in animals evaluated by independent groups (type of model, methodological approaches, propolis composition, supplementation period, and concentration and dosage, among others), evidence has suggested propolis and its main flavonoids as neuroprotective agents, preserving brain tissues against many forms of neurotoxicity [ 67 , 68 , 69 , 70 , 71 , 72 , 73 ]. Barros Silva and collaborators [ 74 ] described a decrease in dopaminergic loss triggered by unilateral injection of 6-OHDA in the SNc and striatum of rats after administration of caffeic acid, a flavonoid present in Brazilian green propolis.…”

Section: Discussionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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Patients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor features. Nutrition is a key modifiable determinant of chronic disease. This study aimed to assess the effects of propolis on cardiological features, heart rate (HR) and heart rate variability (HRV) and on nigrostriatal dopaminergic damage, detected by tyrosine hydroxylase (TH) immunoreactivity, in the 6-hydroxydopamine (6-OHDA) rat model of PD. Male Wistar rats were injected bilaterally with 6-OHDA or saline into the striatum and were treated with propolis or water for 40 days. Autonomic function was assessed by time domain parameters (standard deviation of all normal-to-normal intervals (SDNN) and square root of the mean of the squared differences between adjacent normal RR intervals (RMSSD)) of HRV calculated from electrocardiogram recordings. Reductions in HR (p = 1.47 × 10−19), SDNN (p = 3.42 × 10−10) and RMSSD (p = 8.2 × 10−6) detected in parkinsonian rats were reverted by propolis. Propolis attenuated neuronal loss in the substantia nigra (p = 5.66 × 10−15) and reduced striatal fiber degeneration (p = 7.4 × 10−5) in 6-OHDA-injured rats, which also showed significant weight gain (p = 1.07 × 10−5) in comparison to 6-OHDA-lesioned counterparts. Propolis confers cardioprotection and neuroprotection in the 6-OHDA rat model of PD.

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Section: Discussionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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“…Several other flavonoids (flavonoids isolated from honey and blueberry extracts [25,26], kaempferol [27], catechin [28], naringenin [29], and acacetin [30]) potentially inhibited neuro-inflammation by controlling the pro-inflammatory biomarkers, such as nuclear factor kappa light chain enhancer of activated B cells (NF-κB) iNOS, TNF-α, NADPH oxidase, and so forth. Curcumin, resveratrol, EGb 761 (isolated from Ginkgo biloba ), cinnamon, and various groups of plant-based compounds exhibited the potential of being intervened in neuro-inflammatory diseases [31].…”

Section: Natural Products As the Future Of Neuroprotective Drugsmentioning

confidence: 99%

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

et al. 2019

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Neuroprotection is the preservation of function and networks of neural tissues from damages caused by various agents, as well as neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Huntington’s diseases, and multiple sclerosis. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against development of neurodegenerative diseases. Our review discusses neuropharmacological mechanisms for preventive and therapeutic effects of hesperidin in neurodegenerative diseases. In addition, the review examines clinical evidence confirming its neuroprotective function. Various cellular and animal models specific to neurodegenerative diseases have been conducted to evaluate the underlying neuropharmacological mechanisms of hesperidin. Neuroprotective potential of this flavonoid is mediated by improvement of neural growth factors and endogenous antioxidant defense functions, diminishing neuro-inflammatory and apoptotic pathways. Despite the various preclinical studies on the role of hesperidin in the neurodegenerative diseases, less is known about its definite effect on humans. A limited number of clinical trials showed that hesperidin-enriched dietary supplements can significantly improve cerebral blood flow, cognition, and memory performance. Further clinical trials are also required for confirming neuroprotective efficacy of this natural flavonoid and evaluating its safety profile.

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“…Nowadays, complementary and alternative medicine is widely applied alongside the methods mentioned (Pourmasoumi et al, ; Vishnu, Mini, & Thankappan, ). In this context, the complementary use of apitherapy—the medical use of honey bee products (royal jelly, propolis, bee venom, pollen, and honey)—for the treatment of diseases is increasing globally (Farooqui & Farooqui, ; Hadi et al, ). These products are easily available and free from serious adverse effects, making honey bee products a popular choice (Sforcin, Bankova, & Kuropatnicki, ).…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, complementary and alternative medicine is widely applied alongside the methods mentioned Vishnu, Mini, & Thankappan, 2017). In this context, the complementary use of apitherapy-the medical use of honey bee products (royal jelly, propolis, bee venom, pollen, and honey)-for the treatment of diseases is increasing globally (Farooqui & Farooqui, 2017;.…”

mentioning

confidence: 99%

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Karimian

Hadi

Pourmasoumi

et al. 2019

Phytotherapy Research

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Background and Objectives The impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM). Methods A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random‐effects model was applied in the meta‐analysis to compensate for potential heterogeneity among the included studies. Results Six randomized controlled trials comprising 373 participants were included in the systematic review and meta‐analysis. The results of the meta‐analysis revealed significant reductions in fasting plasma glucose (−13.51 mg/dl; 95% CI [−24.98, −2.04]) and hemoglobin A1C (−0.52%; 95% CI [−0.94, −0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (−0.53 pmol/L; 95% CI [−1.69, 0.63]) or homeostasis model assessment of insulin resistance (−0.543; 95% CI [−1.72, 0.64]). Conclusion This systematic review and meta‐analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.

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Apitherapy

Cited by 6 publications

References 106 publications

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

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