Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity <i>In Vivo</i>

Budhraja, Amit; Gao, Ning; Zhang, Zhuo; Son, Young-Ok; Cheng, Senping; Wang, Xin; Ding, Song‐Ze; Hitron, Andrew; Chen, Gang; Luo, Jia; Shi, Xianglin

doi:10.1158/1535-7163.mct-11-0343

Cited by 91 publications

(62 citation statements)

References 38 publications

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“…In addition to inducing apoptosis in leukemia cells, apigenin-7 glycoside has been shown to induce granulocyte differentiation that was confirmed by the presence of significant amounts of CD11b positive cells [186]. Evidence also suggests that PI3K/Akt and JNK kinases and their related pathways are potential targets for apigenin-induced apoptosis in leukemia cells [187]. Apigenin-induced expressions of α, β, and γ globin genes increased the expression of glycosporin as a marker for differentiation.…”

Section: 0 Effect Of Apigenin In Various Human Cancersmentioning

confidence: 99%

Plant Flavone Apigenin: an Emerging Anticancer Agent

et al. 2017

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Research in cancer chemoprevention provides convincing evidence that increased intake of vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals present therein provide beneficial anti-inflammatory and antioxidant properties that serve to improve the cellular microenvironment. Compounds known as flavonoids categorized anthocyanidins, flavonols, flavanones, flavonols, flavones, and isoflavones have shown considerable promise as chemopreventive agents. Apigenin (4′, 5, 7-trihydroxyflavone), a major plant flavone, possessing antioxidant, anti-inflammatory, and anticancer properties affecting several molecular and cellular targets used to treat various human diseases. Epidemiologic and case-control studies have suggested apigenin reduces the risk of certain cancers. Studies demonstrate that apigenin retain potent therapeutic properties alone and/or increases the efficacy of several chemotherapeutic drugs in combination on a variety of human cancers. Apigenin’s anticancer effects could also be due to its differential effects in causing minimal toxicity to normal cells with delayed plasma clearance and slow decomposition in liver increasing the systemic bioavailability in pharmacokinetic studies. Here we discuss the anticancer role of apigenin highlighting its potential activity as a chemopreventive and therapeutic agent. We also highlight the current caveats that preclude apigenin for its use in the human trials.

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Section: 0 Effect Of Apigenin In Various Human Cancersmentioning

confidence: 99%

Plant Flavone Apigenin: an Emerging Anticancer Agent

et al. 2017

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“…Many of the chemoprevetive effects of apigenin are related to its inhibition of Akt activity. It is well known that PI3K/Akt signaling plays an important role in inhibiting apoptosis for cancer cell survival and growth, and apigenin has been reported in numerous studies in vitro as well as in vivo to enhance apoptosis by inactivation of Akt [113, 114]. Apigenin has also been demonstrated to inhibit ovarian tumor metastasis through down-regulation of MMP-9, which is mediated by Akt signaling [91].…”

Section: Inhibition Of Pi3k/akt and Mtor Signaling Pathways By Apimentioning

confidence: 99%

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Tong¹,

Pelling²

2013

ACAMC

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Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.

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“…Apigenin inactivates Akt to trigger apoptosis in human prostate cancer in vitro and in vivo (Kaur et al, 2008). Apigenin also induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo (Budhraja et al, 2012). Apigenin inhibits expression of VEGF and angiogenesis in human lung cancer cells (Liu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

Dai

Wie

Fai

et al. 2016

Toxicology and Applied Pharmacology

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Apigenin is a natural flavonoid which possesses multiple anti-cancer properties such as anti-proliferation, anti-inflammation, and anti-metastasis in many types of cancers including colorectal cancer. Neural precursor cell expressed developmentally downregulated 9 (NEDD9) is a multi-domain scaffolding protein of the Cas family which has been shown to correlate with cancer metastasis and progression. The present study investigates the role of NEDD9 in apigenin-inhibited cell migration, invasion, and metastasis of colorectal adenocarcinoma DLD1 and SW480 cells. The results show that knockdown of NEDD9 inhibited cell migration, invasion, and metastasis and that overexpression of NEDD9 promoted cell migration and invasion of DLD1 cells and SW4890 cells. Apigenin treatment attenuated NEDD9 expression at protein level, resulting in reduced phosphorylations of FAK, Src, and Akt, leading to inhibition on cell migration, invasion, and metastasis of both DLD1 and SW480 cells. The present study has demonstrated that apigenin inhibits cell migration, invasion, and metastasis through NEDD9/Src/Akt cascade in colorectal cancer cells. NEDD9 may function as a biomarker for evaluation of cancer aggressiveness and for selection of therapeutic drugs against cancer progression.

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Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo

Cited by 91 publications

References 38 publications

Plant Flavone Apigenin: an Emerging Anticancer Agent

Plant Flavone Apigenin: an Emerging Anticancer Agent

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

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