Apigenin and Exposure to Low Dose Gamma Radiation Ameliorate Acetic Acid-Induced Ulcerative Colitis in Rats

Shibrya, Eman E; Rashed, Rasha R.; Fattah, Mai A. Abd El; El‐Ghazaly, Mona A.; Kenawy, Sanaa A.

doi:10.1177/15593258231155787

Cited by 6 publications

(3 citation statements)

References 69 publications

(91 reference statements)

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“…It inhibits the cell cycle, enhances the activity of hepatic detoxification enzymes, and possesses a limited antiinflammatory effect. Nevertheless, these findings agreed with other studies where the inhibitory effects of apigenin on cyclooxygenase-2 (COX-2) and monocyte adhesion to the endothelium of the umbilical vein were demonstrated through the downregulation of cellular adhesion molecules, including vascular cell adhesion protein 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) (Toma et al, 2020;Shibrya et al, 2023).…”

Section: Acetic Acid Testsupporting

confidence: 92%

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

Fahd,

Saliem

2024

AAVS

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This article aims to determine the analgesic impact of Apigenin and Diclofenac in mice model. In the beginning, 84 male albino mice were selected, acclimated, and categorized into four equal groups: The 1st tested by the hot plate, the 2nd treated with acetic acid, the 3rd examined by application 10 μl of 2% formalin solution and the 4th was examined by the tail-flick test. Within each experiment, the study mice were subdivided equally into three subgroups; the 1st was administered only distilled water (control), the 2nd was drenched with apigenin (50 mg/Kg B.W.) orally, and the 3rd was drenched only diclofenac (0.71 mg/kg B.W). The hot plate's outcomes showed that the animals treated with apigenin significantly increased in time than with diclofenac. The number of writhes in both apigenin and diclofenac-treated groups has been significantly reduced in the acetic acid test when compared to the control. The formalin test revealed that both apigenin and diclofenac-treated groups reported significantly lower flinches and licks than the control. For the tail-flick test, the results have significantly increased in withdrawal time in apigenin and diclofenac-treated groups than with the control; with the ability of apigenin to relieve the pain when compared with diclofenac.

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Section: Acetic Acid Testsupporting

confidence: 92%

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

Fahd,

Saliem

2024

AAVS

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“…They modulated colon weight/length (W/L) ratio, body weight (BW), and disease activity index (DAI). This study concluded that apigenin showed therapeutic benefits in ulcerative colitis management [ 159 ]. The objective of the study was to examine the intestinal anti-inflammatory effects of apigenin K, which is a soluble form of apigenin, in two rat colitis models: the trinitrobenzene sulfonic acid model and the dextran sulfate sodium model.…”

Section: Exploring the Pharmacological Potential Of Apigenin Through ...mentioning

confidence: 99%

Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment

Allemailem,

Almatroudi,

Alharbi

et al. 2024

Biomedicines

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Apigenin is a powerful flavone compound found in numerous fruits and vegetables, and it offers numerous health-promoting benefits. Many studies have evidenced that this compound has a potential role as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the risk of pathogenesis. It has also been found to positively affect various systems in the body, such as the respiratory, digestive, immune, and reproductive systems. Apigenin is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health. Multiple studies have reported that this compound is capable of suppressing various types of cancer through the induction of apoptosis and cell-cycle arrest, suppressing cell migration and invasion, reduction of inflammation, and inhibiting angiogenesis. When used in combination with other drugs, apigenin increases their efficacy, reduces the risk of side effects, and improves the response to chemotherapy. This review broadly analyzes apigenin’s potential in disease management by modulating various biological activities. In addition, this review also described apigenin’s interaction with other compounds or drugs and the potential role of nanoformulation in different pathogeneses. Further extensive research is needed to explore the mechanism of action, safety, and efficacy of this compound in disease prevention and treatment.

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“…Ulcerative colitis (UC) is a chronic bowel disorder resulting in disruption of the integrity of the colon as characterized by persistent colorectal inflammation and ulceration. No single collective etiology underlies the pathology of UC and instead, it has a multifactorial course involving environmental, hereditary, and immune-mediated causes ( Shibrya et al, 2023 ). The incidence of UC in different regions of the world ranges from 0.6 to 24.3 per 100,000 individuals.…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Rehman,

Saleem,

Raza

et al. 2024

Front. Chem.

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Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for this disease is available.Objective: The objective of the current study was to assess the effect of Calliandra haematocephala on inflammatory mediators and oxidative stress markers for the exploration of its anti-ulcerative colitis activity in rat models of acetic acid-induced ulcerative colitis.Methods: Methanolic and n-hexane extracts of areal parts of the plant were prepared by cold extraction method. Phytochemical analysis of both extracts was performed by qualitative analysis, quantitative methods, and high-performance liquid chromatography (HPLC). Prednisone at 2 mg/kg dose and plant extracts at 250, 500, and 750 mg/kg doses were given to Wistar rats for 11 days, which were given acetic acid on 8th day through the trans-rectal route for the induction of ulcerative colitis. A comparison of treatment groups was done with a normal control group and a colitis control group. To evaluate the anti-ulcerative colitis activity of Calliandra haematocephala, different parameters such as colon macroscopic damage, ulcer index, oxidative stress markers, histopathological examination, and mRNA expression of pro and anti-inflammatory mediators were evaluated. mRNA expression analysis was carried out by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR).Results: The phytochemical evaluation revealed polyphenols, flavonoids, tannins, alkaloids, and sterols in both extracts of the plant. Results of the present study exhibited that both extracts attenuated the large bowel inflammation and prevented colon ulceration at all tested doses. Macroscopic damage and ulcer scoreswere significantly decreased by both extracts. Malondialdehyde (MDA) levels and nitrite/nitrate concentrations in colon tissues were returned to normal levels while superoxide dismutase (SOD) activity was significantly improved by all doses. Histopathological examination exhibited that both extracts prevented the inflammatory changes, cellular infiltration, and colon thickening. Gene expression analysis by RT-qPCR revealed the downregulation of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) whereas the anti-inflammatory cytokines including Interleukin-4 (IL-4) and Interleukin-10 (IL-10) were found to be upregulated in treated rats.Conclusion: It was concluded based on study outcomes that methanolic and n-hexane extracts of Calliandra haematocephala exhibited anti-ulcerative colitis activity through modulation of antioxidant defense mechanisms and the immune system. In this context, C. haematocephala can be considered as a potential therapeutic approach for cure of ulcerative colitis after bioassay-directed isolation of bioactive phytochemicals and clinical evaluation.

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Apigenin and Exposure to Low Dose Gamma Radiation Ameliorate Acetic Acid-Induced Ulcerative Colitis in Rats

Cited by 6 publications

References 69 publications

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

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