Apigenin Ameliorates Oxidative Stress-induced Neuronal Apoptosis in SH-SY5Y Cells

Kim, Yeo Jin; Cho, Eun Ju; Lee, Ah Young; Seo, Weon Taek

doi:10.48022/mbl.2009.09006

Cited by 6 publications

(6 citation statements)

References 63 publications

(69 reference statements)

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“…Apigenin decreased oxidative stress-induced neuronal apoptosis in neuronal cells (Kim et al, 2021). Esculetin ameliorated cognitive impairments that were induced by cerebral ischemia in mice (Xu et al, 2019).…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, caffeic acid improves memory impairment by ameliorating insulin and leptin signaling in high‐fat diet‐induced hyperinsulinemic rats (Chang et al, 2015). These previous studies reported cognitive improvement effects and neuroprotective activity of active compounds from AY such as apigenin, esculetin, caffeic acid, respectively (Chang et al, 2015; Kim et al, 2021; Xu et al, 2019). However, cognitive improvement effects of natural plant, EFAY, containing apigenin, esculetin, caffeic acid in HFD‐induced cognitive impairment mice model has not been investigated.…”

Section: Discussionmentioning

confidence: 94%

“…Since these active substances have shown neuronal protection, AY is expected to exhibit a protective effect against HFD‐induced learning and memory impairment. Apigenin decreased oxidative stress‐induced neuronal apoptosis in neuronal cells (Kim et al, 2021). Esculetin ameliorated cognitive impairments that were induced by cerebral ischemia in mice (Xu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of Aster yomena (Kitam.) Honda from cognitive dysfunction induced by high‐fat diet

Kim

Lee

et al. 2022

Journal of Food Biochemistry

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In our study, we investigated whether Aster yomena (Kitam.) Honda (AY) improved cognitive impairment which results from consumption of high-fat diet (HFD). When ethyl acetate fraction from AY (EFAY) was administered to C57BL/6J mice fed with 60% HFD, EFAY significantly enhanced cognitive ability that was impaired by HFD in T-maze test and novel object recognition test. Furthermore, EFAY increased memory and learning functions that were proven during Morris water maze test. We further elucidated protective mechanisms of EFAY against cognitive decline that resulted from obesity by western blotting. In the brain, HFD increased neuronal inflammation and disturbed insulin receptor substrate-1 (IRS-1)/Akt pathway. However, EFAY significantly downregulated inflammation-related protein expressions such as nuclear factor-κB interleukin-1β, inducible nitric oxide synthase and cyclooxygenase-2, compared with the HFD-fed control group. Furthermore, the IRS-1/Akt pathway was regulated by EFAY, indicating that EFAY ameliorated insulin resistance in the brain. Practical applicationsObesity and its complications increase the risk for developing cognitive dysfunction such as dementia. Administration of ethyl acetate fraction from AY (EFAY)-attenuated cognitive and memory impairment by inhibitions of neuronal oxidative stress and low-grade chronic inflammation in high-fat diet (HFD)-induced cognitive impairment mouse model. In addition, EFAY-administered mice disturbed cerebral insulin receptor substrate-1 (IRS-1)/Akt pathway. These data suggest that EFAY-improved cognitive impairment induced by HFD through modulation of insulin resistance and inflammation. Therefore, we proposed that AY could be a potential agent to prevent cognitive dysfunction induced by obesity and insulin resistance.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Protective effects of Aster yomena (Kitam.) Honda from cognitive dysfunction induced by high‐fat diet

Kim

Lee

et al. 2022

Journal of Food Biochemistry

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“…Further studies are needed to elucidate the precise molecular mechanisms responsible for EFAY's cognitive-enhancing effect. Active compounds such as apigenin, esculetin, and caffeic acid, which have been found to possess neuroprotective and/or antioxidative properties in other studies [61,62], warrant further investigation in this regard.…”

Section: Japanese Aster [Aster Yomena (Kitam) Honda]mentioning

confidence: 99%

Review of Plant Extracts and Active Components: Mechanisms of Action for the Treatment of Obesity-Induced Cognitive Impairment

de la Peña,

Afable,

Dahilig-Talan

et al. 2023

Brain Sciences

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Obesity has been shown to negatively impact cognitive functions, but effective treatments for obesity-induced cognitive impairment are lacking. Natural dietary and plant products, functional foods, and plant-derived compounds have gained attention as potential remedies in part due to the nootropic properties of plants and certain plant-derived agents. This review discusses plant extracts and plant-derived substances that have been shown to ameliorate obesity-induced cognitive impairment in animal models. Mechanistic evaluations of their therapeutic effects are also summarized. A literature search was conducted using PubMed and Google Scholar databases, resulting in the review of 27 English language articles meeting the inclusion criteria. The nine plants (e.g., Ashwagandha, Adzuki bean, and olive) and 18 plant-derived substances (e.g., curcumin, Huperzine A, and Roxburgh’s jewel orchid polysaccharides) included in this review improved obesity-induced cognitive impairment through several mechanisms, including attenuation of neuroinflammation, improvement in both central and peripheral insulin resistance, enhancement of neuroprotection and neurogenesis, and modulation of the synthesis and release of cognition-associated neurotransmitters. Based on these findings, plants and plant-derived substances may hold promise for the prevention and treatment of obesity-induced cognitive impairment. Further research is warranted to explore the clinical potential of these plant-derived treatments and to elucidate their underlying molecular mechanisms.

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“…Further, C. crispus is known to possess strong anti-oxidative effects [ 9 ]. Apigenin, one of the active constituents from milk thistles, was well documented to possess various biological activities including anti-oxidant, anti-inflammatory, neuroprotective and anti-cancer effects [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Apigenin Isolated from Carduus crispus Protects against H2O2-Induced Oxidative Damage and Spermatogenic Expression Changes in GC-2spd Sperm Cells

Kopalli

Yoo²,

Kim

et al. 2022

Molecules

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Testicular oxidative stress is one of the most common factors underlying male infertility. Welted thistle, Carduus crispus Linn., and its bioactive principles are attracting scientific interest in treating male reproductive dysfunctions. Here, the protective effects of apigenin isolated from C. crispus against oxidative damage induced by hydrogen peroxide (H2O2) and dysregulation in spermatogenesis associated parameters in testicular sperm cells was investigated. Cell viabilities, ROS scavenging effects, and spermatogenic associated molecular expressions were measured by MTT, DCF-DA, Western blotting and real-time RT-PCR, respectively. A single peak with 100% purity of apigenin was obtained in HPLC conditions. Apigenin treated alone (2.5, 5, 10 and 20 µM) did not exhibit cytotoxicity, but inhibited the H2O2-induced cellular damage and elevated ROS levels significantly (p < 0.05 at 5, 10 and 20 µM) and dose-dependently. Further, H2O2-induced down-regulation of antioxidant (glutathione S-transferases m5, glutathione peroxidase 4, and peroxiredoxin 3) and spermatogenesis-associated (nectin-2 and phosphorylated-cAMP response element-binding protein) molecular expression in GC-2spd cells were attenuated by apigenin at both protein and mRNA levels (p < 0.05). In conclusion, our study showed that apigenin isolated from C. crispus might be an effective agent that can protect ROS-induced testicular dysfunctions.

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Apigenin Ameliorates Oxidative Stress-induced Neuronal Apoptosis in SH-SY5Y Cells

Cited by 6 publications

References 63 publications

Protective effects of Aster yomena (Kitam.) Honda from cognitive dysfunction induced by high‐fat diet

Protective effects of Aster yomena (Kitam.) Honda from cognitive dysfunction induced by high‐fat diet

Review of Plant Extracts and Active Components: Mechanisms of Action for the Treatment of Obesity-Induced Cognitive Impairment

Apigenin Isolated from Carduus crispus Protects against H2O2-Induced Oxidative Damage and Spermatogenic Expression Changes in GC-2spd Sperm Cells

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