Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis

Zhao, Xuerong; Wang, Zhuoya; Wu, Guanlin; Yin, Lianhong; Xu, Lina; Wang, Ning; Peng, Jinyong

doi:10.1016/j.jconrel.2023.12.038

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…Thus, GSH/GPX4 is the core pathway for regulating ferroptosis in vivo ( Dong et al, 2023 ; Zhou et al, 2023 ; Xia et al, 2024 ). Many studies have shown that ferroptosis is very important in testicular I/R injuries and that inhibiting oxidative stress and ferroptosis can effectively improve such injuries ( Li et al, 2018 ; Xiang et al, 2023 ; Zhao et al, 2024 ). Although many studies have been conducted on testicular I/R injuries, clinical treatment methods are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

Jiang,

Liu,

Dang

et al. 2024

Front. Pharmacol.

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Testicular torsion is a critical urologic condition for which testicular detorsion surgery is considered irreplaceable as well as the golden method of reversal. However, the surgical treatment is equivalent to a blood reperfusion process, and no specific drugs are available to treat blood reperfusion injuries. Salidroside (SAL) is one of the main effective substances in rhodiola, which has been shown to have antioxidant and antiapoptosis activities. This study was designed to determine whether SAL exerted a protective effect on testicular ischemia-reperfusion (I/R) injury. In this study, the I/R injury model of the testes and reoxygenation (OGD/R) model were used for verification, and SAL was administered at doses of 100 mg/kg and 0.05 mmol/L, respectively. After the experiments, the testicular tissue and TM4 Sertoli cells were collected for histopathologic and biochemical analyses. The results revealed that SAL improves the structure of testicular tissue and regulates the oxidation–antioxidation system. To further understand the molecular mechanisms of SAL in treating testicular I/R injuries, transcriptomics and metabonomics analyses were integrated. The results show that the Nfr2/HO-1/GPX4/ferroptosis signaling pathway is enriched significantly, indicating that it may be the main regulatory pathway for SAL in the treatment of testicular I/R injuries. Thereafter, transfection with Nrf2 plasmid–liposome was used to reverse verify that the Nfr2/HO-1/GPX4/ferroptosis signaling pathway was the main pathway for SAL anti-testicular I/R injury treatment. Thus, it is suggested that SAL can protect against testicular I/R injuries by regulating the Nfr2/HO-1/GPX4 signaling pathway to inhibit ferroptosis and that SAL may be a potential drug for the treatment of testicular I/R injuries.

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Section: Introductionmentioning

confidence: 99%

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

Jiang,

Liu,

Dang

et al. 2024

Front. Pharmacol.

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Copper‐Based Composites Nanoparticles Improve Triple‐Negative Breast Cancer Treatment with Induction of Apoptosis‐Cuproptosis and Immune Activation

Wang,

Liu,

Peng

et al. 2024

Adv Healthcare Materials

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The synergistic effect of apoptosis and cuproptosis, along with the activation of the immune system, presents a promising approach to enhance the efficacy against triple‐negative breast cancer (TNBC). Here, two prodrugs are synthesized: a reactive oxygen species (ROS)‐responsive prodrug PEG‐TK‐DOX and a glutathione (GSH)‐responsive prodrug PEG‐DTPA‐SS‐CPT. These prodrugs are self‐assembled and chelated Cu2+ to prepare nanoparticle PCD@Cu that simultaneously loaded doxorubicin (DOX), camptothecin (CPT), and Cu2+. The elevated levels of ROS and GSH in TNBC cells disrupted the PCD@Cu structure, leading to the release of Cu+, DOX, and CPT and the depletion of GSH. DOX and CPT triggered apoptosis with immunogenic cell death (ICD) in TNBC cells. Simultaneously, PCD@Cu downregulated the expression of copper transporting ATPase 2 (ATP7B), causing a significant accumulation of copper ions in TNBC cells. This further induced the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase (DLAT) and downregulation of iron‐sulfur (Fe‐S) cluster proteins, ultimately leading to cuproptosis and ICD in TNBC. In vitro and in vivo experiments confirmed that PCD@Cu induced apoptosis and cuproptosis in TNBC and activated the immune system, demonstrating strong anti‐tumor capabilities. Moreover, PCD@Cu exhibited an excellent biosafety profile. Overall, this study provides a promising strategy for effective TNBC therapy.

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Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2

Gao,

Cai,

Bian

et al. 2024

Biomedicine & Pharmacotherapy

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Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis

Cited by 7 publications

References 35 publications

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

Copper‐Based Composites Nanoparticles Improve Triple‐Negative Breast Cancer Treatment with Induction of Apoptosis‐Cuproptosis and Immune Activation

Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2

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