Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum

Singh, Sheo B.; Zink, Deborah L.; Polishook, Jon D.; Dombrowski, Anne W.; Darkin-Rattray, Sandra J.; Schmatz, Dennis M.; Goetz, Michael

doi:10.1016/0040-4039(96)01844-8

Cited by 136 publications

(123 citation statements)

References 8 publications

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…Both new analogs, as noted, lack the 9,10-epoxide and instead bear a 9-hydroxyl. Other cyclotetrapeptides have been reported which are unsubstituted at either the 9-or 10-positions of the decanoic acid, specifically apicidin (48) and its N-desmethoxy fermentation congener, apicidin A (49) [80]. Fusarium pallidoroseum produced both of these fungal metabolites, originally identified during natural products screening for antiprotozoal activity.…”

Section: Cyclic Histone Deacetylase In-hibitorsmentioning

confidence: 98%

Histone Deacetylase: A Target for Antiproliferative and Antiprotozoal Agents

Meinke¹,

Liberator²

2001

CMC

108

View full text Add to dashboard Cite

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. It is well-established that in transcriptionally active chromatin, histones generally are hyperacetylated and, conversely, hypoacetylated histones are coincident with silenced chromatin. Revived interest in these enzymatic pathways and how they modulate eukaryotic transcription has led to the identification of multiple cofactors whose complex interplay with HDAC affects gene expression. Concurrent with these discoveries, screening of natural product sources yielded new small molecules that were subsequently identified as potent inhibitors of HDAC. While predominantly identified using antiproliferative assays, the biological activity of these new HDAC inhibitors also encompasses significant antiprotozoal, antifungal, phytotoxic and antiviral applications. These newly discovered HDAC inhibitors served as lead structures for the development of improved derivatives including related reagents with considerable potential as tools to further elucidate the mechanism of transcriptional regulation.

show abstract

Section: Cyclic Histone Deacetylase In-hibitorsmentioning

confidence: 98%

Histone Deacetylase: A Target for Antiproliferative and Antiprotozoal Agents

Meinke¹,

Liberator²

2001

CMC

108

View full text Add to dashboard Cite

show abstract

“…Marine sponges are a source of diverse peptides having been reported widely throughout the phylum with a range of biological activities (see [141] for a review of bioactive sponge peptides). Cyclic peptides are commonly observed as fungal metabolites [142][143][144]. Sponges often form associations with fungi and it has been speculated that the azumamides could originate from a spongeassociated fungal source rather than the sponge itself [145].…”

Section: Peptidesmentioning

confidence: 99%

Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae

2016

View full text Add to dashboard Cite

Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associated biological activities. A diverse group of 190 compounds have been reported from over 40 specimens contained in 49 references. Over half of the studies have reported on the biological activities for the compounds isolated. The polyketides, in particular the macrolides, displayed potent cytotoxic activities (

show abstract

“…, and cyclo-(Phe-Tyr) (4) by comparison of their spectroscopic data with the literature [11][12][13], respectively.…”

mentioning

confidence: 99%