Apical intercalated cell cluster: A distinct sensory regulator in the amygdala

Asede, Douglas; Doddapaneni, Divyesh; Chavez, Abigail; Okoh, James; Ali, Sabah; Von-Walter, Carolyn; Bolton, M. McLean

doi:10.1016/j.celrep.2021.109151

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…The regions observed to show significantly greater functional connectivity with the dorsal striatum included a subregion of the HPC, superior colliculus, bed nucleus of stria terminalis. The role of the dorsal striatum in regards to fear and anxiety are supported by recent work indicating its synaptic connectivity arising from apical intercalated cells in the amygdala, which regulate fear conditioning in mice via inputs from thalamic, temporal association cortex and basolateral amygdala nuclei (Asede et al, 2021). Finally, we should note that age differences between young (1-2mo) and older adult (5-19mo) wildtype littermates of the transgenic Arcβ familial amyloidosis mouse have been reported (Grandjean et al, 2014b).…”

Section: Discussionmentioning

confidence: 60%

Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles

Febo,

Mahar,

Rodriguez

et al. 2024

Front. Aging Neurosci.

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IntroductionThe differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported, but the functional neural circuitry warrants further investigation.MethodsWe assessed age variations in affective behaviors and functional connectivity in male and female C57BL6/J mice. Mice aged 10, 30 and 60 weeks (wo) were tested over 8 weeks for open field activity, sucrose preference, social interactions, fear conditioning, and functional neuroimaging. Prefrontal cortical and hippocampal tissues were excised for metabolomics.ResultsOur results indicate that young and old mice differ significantly in affective behavioral, functional connectome and prefrontal cortical-hippocampal metabolome. Young mice show a greater responsivity to novel environmental and social stimuli compared to older mice. Conversely, late middle-aged mice (60wo group) display variable patterns of fear conditioning and during re-testing in a modified context. Functional connectivity between a temporal cortical/auditory cortex network and subregions of the anterior cingulate cortex and ventral hippocampus, and a greater network modularity and assortative mixing of nodes was stronger in young versus older adult mice. Metabolome analyses identified differences in several essential amino acids between 10wo mice and the other age groups.DiscussionThe results support differential expression of ‘emotionality’ across distinct stages of the mouse lifespan involving greater prefrontal-hippocampal connectivity and neurochemistry.

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Section: Discussionmentioning

confidence: 60%

Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles

Febo,

Mahar,

Rodriguez

et al. 2024

Front. Aging Neurosci.

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Section: Discussionmentioning

confidence: 93%

Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles

Febo,

Mahar,

Rodriguez

et al. 2023

Preprint

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Differences in affective behavioral expression from early to late adulthood is thought to involve changes in frontal cortical responsiveness to negative valence stimuli. In mice, similar maturational changes in affective behaviors have also been reported but the functional neural circuitry remains unclear. In the present study we investigated age variations in affective behaviors and functional connectivity in male and female C57BL6/J mice. Mice aged 10, 30 and 60 weeks (wo) were tested over 8 weeks for open field activity, sucrose reward preference, social interactions and fear conditioning and functional neuroimaging. Frontal cortical and hippocampal tissues were excised for metabolomics analysis. Our results indicate that young 10wo mice display greater levels of anxiety-like locomotor behavior and develop robust fear conditioning compared to older adult and late middle-aged mice (30-60wo). This was accompanied by greater functional connectivity between a temporal cortical/auditory cortex network and subregions of the anterior cingulate cortex and ventral hippocampus, and a greater network modularity and assortative mixing of nodes in young versus older adult mice. Metabolome analyses identified differences in several essential amino acids between 10wo mice and the other age groups. The results support high ‘emotionality’ in younger versus older adult mice involving greater prefrontal-hippocampal connectivity.

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“…These densely packed GABAergic neurons generate feedforward inhibition in the CeA and the BLA inputs/outputs projecting from the thalamic and cortical areas [254]. The ITC-induced feedforward inhibition can also modulate the inputs to the dorsal striatum as a region contributing to the reward-prediction-error system [255]. Accordingly, the activation of MORs in the ITCs takes part in reward salience.…”

Section: Gabaergic/opioidergic Systems Modulating Feedback and Feedfo...mentioning

confidence: 99%

Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors

et al. 2023

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The functional interplay between the corticolimbic GABAergic and opioidergic systems plays a crucial role in regulating the reward system and cognitive aspects of motivational behaviors leading to the development of addictive behaviors and disorders. This review provides a summary of the shared mechanisms of GABAergic and opioidergic transmission, which modulate the activity of dopaminergic neurons located in the ventral tegmental area (VTA), the central hub of the reward mechanisms. This review comprehensively covers the neuroanatomical and neurobiological aspects of corticolimbic inhibitory neurons that express opioid receptors, which act as modulators of corticolimbic GABAergic transmission. The presence of opioid and GABA receptors on the same neurons allows for the modulation of the activity of dopaminergic neurons in the ventral tegmental area, which plays a key role in the reward mechanisms of the brain. This colocalization of receptors and their immunochemical markers can provide a comprehensive understanding for clinicians and researchers, revealing the neuronal circuits that contribute to the reward system. Moreover, this review highlights the importance of GABAergic transmission-induced neuroplasticity under the modulation of opioid receptors. It discusses their interactive role in reinforcement learning, network oscillation, aversive behaviors, and local feedback or feedforward inhibitions in reward mechanisms. Understanding the shared mechanisms of these systems may lead to the development of new therapeutic approaches for addiction, reward-related disorders, and drug-induced cognitive impairment.

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Apical intercalated cell cluster: A distinct sensory regulator in the amygdala

Abstract: Highlights d ApITCs receive inputs from thalamic nuclei and association cortical areas d Thalamic inputs to apITCs undergo fear learning-related plastic changes d The lateral amygdala is a major synaptic target of apITCs d Activation of apITCs suppresses thalamic inputs to lateral amygdala

Cited by 7 publications

References 48 publications

Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles

Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles

Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles

Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors

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