Apical Hypertrophic Cardiomyopathy in an Adolescent

Abdy, Nicole A.; Valdés, Santiago O.; Sorrell, Vincent L.; Klewer, Scott E.; Barber, Brent J.

doi:10.1111/j.1747-0803.2009.00346.x

Cited by 3 publications

(4 citation statements)

References 28 publications

(33 reference statements)

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“…5 It is a frequent cause of sudden death in young athletes because the complication is favored by strenuous exercise. 3 The cause of sudden death in HCM is arrhythmias, ventricular fibrillation, or sustained ventricular tachycardia. 5 The underlying mechanisms for the same are yet to be fully established.…”

Section: Discussionmentioning

confidence: 99%

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Sudden Cardiac Death in 2 Young Siblings

Kundu¹,

Punia²,

Handa³

et al. 2014

American Journal of Forensic Medicine &Amp; Pathology

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Hypertrophic cardiomyopathy is a disease known for exhibiting phenotypic and genetic heterogeneity. At times, sudden cardiac death may be the first and foremost manifestation of the disease. We report 2 cases of hypertrophic cardiomyopathy causing sudden death, which were diagnosed on autopsy with special emphasis on histopathological findings of this entity. The role of a pathologist cannot be undermined as the disease is a diagnostic challenge often overlooked by the neophytes in the field due to unawareness.

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Section: Discussionmentioning

confidence: 99%

“…3 It can present at any age or may be clinically silent or cause sudden death being detected on autopsy. We report 2 cases of HCM causing sudden death and diagnosed on autopsy with special emphasis on histopathological findings of this entity.…”

mentioning

confidence: 99%

Sudden Cardiac Death in 2 Young Siblings

Kundu¹,

Punia²,

Handa³

et al. 2014

American Journal of Forensic Medicine &Amp; Pathology

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“…Characteristic histological findings include edema, fibrosis, disorganization and bizarre nuclei in the myocardium [ 10 ]. The disease commonly presents on middle age and is most commonly seen in males [ 11 ] though in few cases, it was reported in both adolescents [ 12 ] and advanced age [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Apical Hypertrophic Cardiomyopathy: A Case Report

et al. 2017

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Apical hypertrophic cardiomyopathy (ApHCM) is a rare variant of hypertrophic cardiomyopathy, characterized by a spade-like left ventricular cavity. A 58-year-old African-American female with past medical history of hypertension presented for evaluation of recurrent exertional chest tightness, palpitations and headache. Prior workup including multiple stress tests and angiogram was non-conclusive. Electrocardiogram (EKG) showed characteristic marked T-waves inversions in inferior leads and left ventriculography revealed left ventricle apical hypertrophy with spade like left ventricular cavity that was typical of Yamaguchi syndrome. This case highlights the rare incidence of the disease among African American as well as the challenging diagnostic and presentation features of the disease.

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“…[4][5][6] In our case the patient was adopted, and no information related to his biological family was available. In the Japanese population AHC accounts for about 13% to 25% of the cases of hypertrophic cardiomyopathy, 7 but it is less prevalent in the western population.…”

Section: Discussionmentioning

confidence: 99%

Apical Hypertrophic Cardiomyopathy Presenting as Recurrent Unexplained Syncope

Kasirye¹,

Manne²,

Epperla³

et al. 2011

Clinical Medicine & Research

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A 47-year-old man was referred from an outside facility with complaints of recurrent falls. He had been referred to a neurologist for evaluation of recurrent unexplained syncope. Each event was non-convulsive, random, and preceded by a sudden loss of balance that would progress to falling due to altered mental status. There was no apparent triggering factor, post-event confusion, or loss of either bowel or urinary continence. He had been evaluated twice at a local healthcare facility for these falls, but no cause was identified.He was referred to us on the third presentation after suffering multiple facial and thoracic injuries. He had no evident cardiopulmonary symptoms. Because he was adopted, he had no knowledge of any family history history of cardiac events. His past medical history included bipolar disorder, tobacco abuse, alcohol dependence, and atypical facial pain. His home medications were carbamazepine, lamotrigine, olanzepine, diazepam, and venlafaxine. The only recent change in his medications was a carbamazepine dose reduction because a provider at an outside facility had thought that this might be contributing to his symptoms. On review of his past medical records (more than 10 years prior), left ventricular hypertrophy had been mentioned, but it had not been followed-up in subsequent evaluations. Previous computerized tomography (CT) of the head and neck had been unremarkable.Clinically, the patient was alert, awake, and oriented. Blood pressure was 123/63 mmHg, pulse 83 beats/minute, temperature 99.6ºF, respirations 20 breaths/ minute, and oxygen saturation 95% on room air. He had no orthostatic hypotension. The physical examination was normal except for the multiple facial swellings and left-sided chest wall tenderness he had sustained from the falls. Apical hypertrophic cardiomyopathy (AHC) is a rare variant of hypertrophic cardiomyopathy. Since its description by Sakamoto in 1976 in Japanese patients, our understanding of this entity has evolved. Although cardiac magnetic resonance imaging has emerged as the gold standard for diagnosing AHC, clinical attention must be drawn to the unique electrocardiographic features that provide the initial clues to making the diagnosis. In this case, we present a 47-year-old man with AHC who presented with recurrent syncope, but anomalies on his electrocardiogram went unnoticed on two clinical encounters. He was subsequently admitted to our service and rapidly diagnosed after we observed the very classical findings in the plain twelve lead electrocardiogram done at the time of admission. In a clinical encounter involving a patient presenting with recurrent syncope, special attention must be focused on the electrocardiogram to decipher the unique diagnostic features it might show.

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Apical Hypertrophic Cardiomyopathy in an Adolescent

Cited by 3 publications

References 28 publications

Sudden Cardiac Death in 2 Young Siblings

Sudden Cardiac Death in 2 Young Siblings

Apical Hypertrophic Cardiomyopathy: A Case Report

Apical Hypertrophic Cardiomyopathy Presenting as Recurrent Unexplained Syncope

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