Aphrodisiacs from plant and animal sources—A review of current scientific literature

Melnyk, John P.; Marcone, Massimo F.

doi:10.1016/j.foodres.2011.02.043

Cited by 94 publications

(26 citation statements)

References 67 publications

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“…A collection of dietary supplements ( n = 25) containing ingredients associated with sexual enhancement were obtained for use as matrix blanks to determine if these ingredients interfere with the assay. The dietary supplements were purchased from 8 sources participating in a good manufacturing practice audit program managed by NSF International or dietary supplement verification program by USP .…”

Section: Methodsmentioning

confidence: 99%

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Santillo

Mapa

2018

Drug Testing and Analysis

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Products marketed as dietary supplements for sexual enhancement are frequently adulterated with phosphodiesterase-5 (PDE5) inhibitors, which are erectile dysfunction drugs or their analogs that can cause adverse health effects. Due to widespread adulteration, a rapid screening assay was developed to detect PDE5 inhibitors in adulterated products. The assay employs fluorescence detection and is based on measuring inhibition of PDE5 activity, the pharmacological mechanism shared among the adulterants. Initially, the assay reaction scheme was established and characterized, followed by analysis of 9 representative PDE5 inhibitors (IC , 0.4-4.0 ng mL ), demonstrating sensitive detection in matrix-free solutions. Next, dietary supplements serving as matrix blanks (n = 25) were analyzed to determine matrix interference and establish a threshold value; there were no false positives. Finally, matrix blanks were spiked with 9 individual PDE5 inhibitors, along with several mixtures. All 9 adulterants were successfully detected (≤ 5 % false negative rate; n = 20) at a concentration of 1.00 mg g , which is over 5 times lower than concentrations commonly encountered in adulterated products. A major distinction of the PDE5 inhibition assay is the ability to detect adulterants without prior knowledge of their chemical structures, demonstrating a broad-based detection capability that can address a continuously evolving threat of new adulterants. The PDE5 inhibition assay can analyze over 40 samples simultaneously within 15 minutes and involves a single incubation step and simple data analysis, all of which are advantageous for combating the widespread adulteration of sex-enhancement products.

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Section: Methodsmentioning

confidence: 99%

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Santillo

Mapa

2018

Drug Testing and Analysis

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“…The following herbs have been evaluated in animals and/or humans and may have some effect on reducing ejaculatory latency time: horny goat weed (Epimedium grandiflorum), maca root (Lepidium meyenii), saffron, and Tribulus terrestris [64]. Please see Table 1 for a list of adverse events with use of this medication.…”

Section: Herbal Supplementsmentioning

confidence: 99%

Delayed Ejaculation: Medical and Psychological Treatments and Algorithm

Sadowski

Butcher

Köhler

2015

Curr Sex Health Rep

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Delayed ejaculation (DE) is a challenging disorder to treat. Many clinicians are not comfortable dealing with DE due to a lack of treatment approaches supported by evidence-based medicine. In this review, we discuss the most common treatments and the latest studies that support each DE treatment. The goal of our review is to help clinicians identify and treat patients who present with this disorder. An integrative approach using medications, penile vibratory stimulation, and sexual counseling is important for successful treatment of DE. We propose an algorithm for DE treatment to help guide clinicians. However, an individualized treatment plan should be developed for each unique case due to the multifactorial etiology of DE.

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“…The effect of Pausinystalia yohimba extracts in the treatment of erectile dysfunction has been proven in randomized, placebo-controlled trials (Clark et al, 1984). Several of the spices added to multispecies drink to enhance their taste (e.g., nutmeg, Aframomum melegueta), appear to possess androgenic properties as well (Melnyk and Marcone, 2011). Apart from the anxiogenic properties of Ptychopetalum olacoides (Da Silva et al, 2002), evidence on the therapeutic efficacy of the many Caribbean aphrodisiacs on human erectile dysfunction has yet to be published (Awang, 2011;Melnyk and Marcone, 2011).…”

Section: Unrelated Plants With Similar Propertiesmentioning

confidence: 99%

In search of the perfect aphrodisiac: Parallel use of bitter tonics in West Africa and the Caribbean

Andel

Mitchell

Volpato

et al. 2012

Journal of Ethnopharmacology

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Aphrodisiacs from plant and animal sources—A review of current scientific literature

Cited by 94 publications

References 67 publications

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Delayed Ejaculation: Medical and Psychological Treatments and Algorithm

In search of the perfect aphrodisiac: Parallel use of bitter tonics in West Africa and the Caribbean

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