Apheresis Platelet Concentrates: Correlation of Day One Levels of in Vitro Quality Markers With Corresponding Levels on Days Two to Five of Storage

Effects of a new pathogen‐reduction technology (Mirasol PRT) on functional aspects of platelet concentrates

“…The extent of activation and the subsequent deterioration upon storage, however, differs significantly depending on separation procedures. Comparative studies with flow cytometry techniques indicate, in general, that PLTs collected by the PLT‐rich plasma method showed greater alterations, apheresis procedures could induce moderate changes, and PCs procured from BC show lesser activation 9‐11,23‐25 …”

“…Comparative studies with flow cytometry techniques indicate, in general, that PLTs collected by the PLT-rich plasma method showed greater alterations, apheresis procedures could induce moderate changes, and PCs procured from BC show lesser activation. [9][10][11][23][24][25] Alterations in PLTs harvested through apheresis procedures seem to depend highly on cell separator technology. Modifications in shear stress, biocompatibility of surfaces, and recollection of the PLTs may result in variable degrees of PLT activation and thereby affect the quality of the component.…”

“…During the past several years, a number of groups have studied the morphologic and biochemical changes that occur during preparation and storage of PLTs and how these modifications may result in an impairment of PLT function 9‐11 and even a delayed response to further stimuli 12 . Pathogen inactivation of plasma derivatives is being enforced by several health authorities.…”

Platelet transfusion refractoriness

“…In vitro markers of platelet quality decline by day 5 of storage (Bessos et al , 1996). The TRAP study suggests that platelet age significantly affects CCI (Slichter et al , 2005).…”

Apheresis‐induced platelet activation:comparison of three types of cell separators

“…The platelet storage lesion is well documented in apheresis and random‐donor PCs 5–10 . The initial lesion that evolves during the isolation process seems to be essential for PC quality later during storage 5,6, 11 .…”