Apheresis in Neurological Disorders

Dorst, Johannes

doi:10.3390/jcm9103211

Cited by 1 publication

(1 citation statement)

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“…The most common indications reported in the World apheresis registry are neurological disorders. 7 The use of plasmapheresis to treat neurological and other immune-based illnesses has been commonplace for some time. In spite of their lack of resources and experience, developing nations have been employing it successfully.…”

Section: Discussionmentioning

confidence: 99%

Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital

Dr Tooba Fateen,

Dr Nighat Sultana,

Dr Muhammad Sarwar

et al. 2023

Pak J Med Sci

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Objective: To find the incidence of various complications of therapeutic plasma exchange (TPE) in ICU admitted children and to determine their association with age, gender, blood group and diagnosis of the patients. Methods: In this observational study, data of 24 patients who underwent 125 sessions of TPE was collected from the Pediatric Intensive care unit (PICU) and Hematology department of The Children’s Hospital, Lahore from December 2020 to November 2021. Age, gender, blood group, indications and complications observed during and after the TPE procedure were documented on a pre-designed proforma. The data was analyzed by using SPSS version 23. Quantitative variables were presented in the form of mean and standard deviation. Qualitative variables like gender, blood groups, indications and complications of plasmapheresis were presented as frequency and percentage. Chi square test was applied for comparison of variables. Results: Among the 24 patients, 45.8% were of age group five to ten years with mean age of 7.58 years± 2.04 years and male to female ratio of 0.84:1. Guillain-Barré syndrome (GBS) and Neuromyelitis Optica spectrum disorder (NMO-SD) were the most prevalent among the patients who underwent TPE. Most common complication was hypotension (44.9%), others were febrile reactions (11.6%), unstable vital signs (14.5%) and allergic reactions (24.6%). Blood group, clinical condition and diagnosis of the patient showed significant association with the incidence of TPE related complications. Conclusion: The majority of problems caused by TPE are considered to be minor. Sudden fall in blood pressure, pruritus, urticarial rash and fever are the common adverse consequences among pediatric patients. Blood group and diagnosis of the patient can determine the development of such complications during plasmapheresis procedure. doi: https://doi.org/10.12669/pjms.39.4.7002 How to cite this: Fateen T, Sultana N, Sarwar M, Saqlain N. Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7002 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%