APH-2 and Tax expression are correlated with a HTLV-2 proviral load but not with lymphocytosis

Abstract

International audiencen.

Conference highlights of the 15th international conference on human retrovirology: HTLV and related retroviruses, 4-8 june 2011, Leuven, Gembloux, Belgium

“…Douceron et al . observed that expression of HTLV-2 APH-2 and Tax are correlated with HTLV-2 proviral load, but not with lymphocytosis; consistent with this, APH2 (contrary to HBZ of HTLV-1) did not promote cell proliferation in vitro [ 105 ]. The nuclear localization of complementary strand transcripts of both HTLV-1 and HTLV-2 [ 95 ] might favour viral persistence by reducing translation and exposure of the infected cell to the CTL response while allowing function as a non-coding transcripts.…”