APGW-Amide as an inhibitory neurotransmitter of   ferussac

Liu, Guo Jun; Santos, Divina E.; Takeuchi, Hiroshi; Kamatani, Yoshimi; Minakata, Hiroyuki; Nomoto, Kyosuke; Kubota, I.; Ikeda, Takako; Muneoka, Yojiro

doi:10.1016/0006-291x(91)91943-7

Cited by 38 publications

(2 citation statements)

References 7 publications

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“…Regardless of where the APGWamide transcript came from, the presence of such central projections in the ganglia suggests that APGWamide may be a centrally active transmitter. APGWamide has central effects in other gastropods (Liu et al, 1991;Chen and Walker, 1992).…”

Section: Discussionmentioning

confidence: 99%

Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia

Fan

Croll

et al. 1997

J. Comp. Neurol.

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While much is known about the neural and endocrine mechanisms that control egg laying in the gastropod mollusk Aplysia, relatively little is known about the regulation of male reproductive activity in this simultaneous hermaphrodite. In the present study, we have cloned and sequenced a cDNA that encodes a precursor protein, the predicted posttranslational processing of which presumably generates nine copies of the neuropeptide Ala-Pro-Gly-Trp-NH2 (APGWamide), five connecting peptide sequences, and a C-terminal peptide. The sequence of one connecting peptide is identical to the previously characterized cerebral peptide 1. Northern blot analysis identified two major APGWamide mRNA transcripts (approximately 1.3 kb, approximately 2.4 kb), which were present in central nervous system ganglia, but were most abundant in the right cerebral and right pedal ganglia. Immunohistochemical studies using sexually mature Aplysia demonstrated that the vast majority of APGWamide-like immunoreactivity was localized in 30-40 neurons along the anterior and medial margins of the right cerebral ganglion and in a cluster of 15-20 neurons in the right pedal ganglion. A total of only about ten immunoreactive neurons were located in other ganglia. Immunohistochemistry also demonstrated that APGWamide was present in the reproductive organs that participate in the storage or transport of sperm, including the small hermaphroditic duct (site of sperm storage before mating), the white hemiduct (also known as the copulatory duct), and penial complex. As a group, these data suggest that APGWamide may play a role in regulating male reproductive function in Aplysia, as it does in other gastropods.

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Section: Discussionmentioning

confidence: 99%

Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia

Fan

Croll

et al. 1997

J. Comp. Neurol.

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“…APGWamide has been well studied in molluscs, demonstrating a key role in male copulation behaviour, for example, in the basommatophoran pulmonate freshwater snail Lymnaea stagnalis (Croll and Van Minnen 1992 ; Croll et al 1991 ; Van Golen et al 1995 ; Van Kesteren et al 1995 ; York et al 2012 ). It has also been detected in the CNS of other snails, such as Fusinus ferrugineus (Kuroki et al 1990 ), the African giant snail Achatina fulica (Liu et al 1991 ) and Cornu aspersum (Liu et al 1991 , 1993 ; Chen and Walker 1992 ; Liu and Takeuchi 1993 , 1995 ). FxRIamide, GGNG and insulin-like peptide genes were found at relatively high levels in the mantle, while the foot contained a notable level of myomodulin.…”

Section: Resultsmentioning

confidence: 99%

Development and Interrogation of a Transcriptomic Resource for the Giant Triton Snail (Charonia tritonis)

et al. 2021

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Gastropod molluscs are among the most abundant species that inhabit coral reef ecosystems. Many are specialist predators, along with the giant triton snail Charonia tritonis (Linnaeus, 1758) whose diet consists of Acanthaster planci (crown-of-thorns starfish), a corallivore known to consume enormous quantities of reef-building coral. C. tritonis are considered vulnerable due to overexploitation, and a decline in their populations is believed to have contributed to recurring A. planci population outbreaks. Aquaculture is considered one approach that could help restore natural populations of C. tritonis and mitigate coral loss; however, numerous questions remain unanswered regarding their life cycle, including the molecular factors that regulate their reproduction and development. In this study, we have established a reference C. tritonis transcriptome derived from developmental stages (embryo and veliger) and adult tissues. This was used to identify genes associated with cell signalling, such as neuropeptides and G protein-coupled receptors (GPCRs), involved in endocrine and olfactory signalling. A comparison of developmental stages showed that several neuropeptide precursors are exclusively expressed in post-hatch veligers and functional analysis found that FFamide stimulated a significant (20.3%) increase in larval heart rate. GPCRs unique to veligers, and a diversity of rhodopsin-like GPCRs located within adult cephalic tentacles, all represent candidate olfactory receptors. In addition, the cytochrome P450 superfamily, which participates in the biosynthesis and degradation of steroid hormones and lipids, was also found to be expanded with at least 91 genes annotated, mostly in gill tissue. These findings further progress our understanding of C. tritonis with possible application in developing aquaculture methods.

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Localization of the Neuropeptide APGWamide in Gastropod Molluscs byin SituHybridization and Immunocytochemistry

Lange

Minnen

1998

General and Comparative Endocrinology

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APGW-Amide as an inhibitory neurotransmitter of ferussac

Cited by 38 publications

References 7 publications

Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia

Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia

Development and Interrogation of a Transcriptomic Resource for the Giant Triton Snail (Charonia tritonis)

Localization of the Neuropeptide APGWamide in Gastropod Molluscs byin SituHybridization and Immunocytochemistry

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