2020
DOI: 10.1002/cpe.5846
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APEX2S: A two‐layer machine learning model for discovery of host‐pathogen protein‐protein interactions on cloud‐based multiomics data

Abstract: Presented by the avalanche of biological interactions data, computational biology is now facing greater challenges on big data analysis and solicits more studies to mine and integrate cloud-based multiomics data, especially when the data are related to infectious diseases. Meanwhile, machine learning techniques have recently succeeded in different computational biology tasks. In this article, we have calibrated the focus for host-pathogen protein-protein interactions study, aiming to apply the machine learning… Show more

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Cited by 5 publications
(2 citation statements)
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“…Therefore, one of the imperative topics in every distributed system, similar to cloud and grid computing, is to find the appropriate services depending on the user's demand. To gain the best efficiency, a useful discovery, finding and selection of relevant services are necessary (Chen et al , 2020). However, to the best of our knowledge, a systematic and comprehensive survey about cloud service discovery is rare, at least in recent years.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, one of the imperative topics in every distributed system, similar to cloud and grid computing, is to find the appropriate services depending on the user's demand. To gain the best efficiency, a useful discovery, finding and selection of relevant services are necessary (Chen et al , 2020). However, to the best of our knowledge, a systematic and comprehensive survey about cloud service discovery is rare, at least in recent years.…”
Section: Introductionmentioning
confidence: 99%
“…Meanwhile, machine learning techniques have recently succeeded in different computational biology tasks. For this reason, Chen et al 2 proposed APEX2S, a novel two‐layer machine learning model, for discovery of the protein‐protein interactions data. APEX2S calibrated the focus for host‐pathogen protein‐protein interactions study, aiming to apply machine learning techniques for learning the interactions data and making predictions.…”
mentioning
confidence: 99%