APEX1/miR-24 axis: a promising therapeutic target in endometriosis

Tan, Aili; Ruan, Peng; Sun, Pengxing

doi:10.1007/s00404-021-05963-6

Cited by 3 publications

(1 citation statement)

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“…BAX mRNA levels are decreased in endometriotic tissue compared with those in normal endometrium [ 116 ]. APEX1 and miR-24 are highly expressed in endometriotic lesions; silencing of these genes elevates BAX expression [ 117 ]. CPEB3 increases BAX expression in endometriosis with decreased expression of MMP-2 and MMP-9, which are related to cell mobility and adhesion [ 118 ].…”

Section: Transcriptome Analysis Of Endometriosis Using Micro-array Or...mentioning

confidence: 99%

Molecular Mechanisms of Endometriosis Revealed Using Omics Data

Cho

2023

Biomedicines

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Endometriosis is a gynecological disorder prevalent in women of reproductive age. The primary symptoms include dysmenorrhea, irregular menstruation, and infertility. However, the pathogenesis of endometriosis remains unclear. With the advent of high-throughput technologies, various omics experiments have been conducted to identify genes related to the pathophysiology of endometriosis. This review highlights the molecular mechanisms underlying endometriosis using omics. When genes identified in omics experiments were compared with endometriosis disease genes identified in independent studies, the number of overlapping genes was moderate. However, the characteristics of these genes were found to be equivalent when functional gene set enrichment analysis was performed using gene ontology and biological pathway information. These findings indicate that omics technology provides invaluable information regarding the pathophysiology of endometriosis. Moreover, the functional characteristics revealed using enrichment analysis provide important clues for discovering endometriosis disease genes in future research.

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Section: Transcriptome Analysis Of Endometriosis Using Micro-array Or...mentioning

confidence: 99%