Abstract. The most active starbursts are found in galaxies with the highest IR luminosities, with peak star formation rates and e ciencies that are over an order of magnitude higher than in normal disk systems. These systems are almost exclusively on-going mergers. In this review I explore the conditions needed for interactions to experience such a phase by comparing two systems at similar stages of merging but quite di erent IR luminosities: NGC 4038/9 and Arp 299. These observations show that the most intense starbursts occur at the sites with the highest gas densities, which is a general result for IR luminous mergers. Observations and theory both suggest that the strength of the merger induced starburst depends on the internal structure of the progenitors, the amount and distribution of the gas, and the violence of the interaction. In particular, interactions involving progenitors with dense bulges, gas-rich disks, and/or a retrograde spin are expected to preferentially lead to large amounts of gaseous dissipation, although the interplay b e t w een these parameters is unknown. A major outstanding question is how the e ects of feedback alter these conclusions.