Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding

Heinonen, Miika; Purhonen, Anna-Kaisa; Miettinen, Pekka; Pääkkönen, Matti; Pirinen, Eija; Alhava, Esko; Åkerman, Karl E.O.; Herzig, Karl‐Heinz

doi:10.1016/j.regpep.2005.05.003

Cited by 210 publications

(166 citation statements)

References 45 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Heinnonen et al reported that apelin levels correlated positively with BMI. 12 In our study, BMI was significantly different in normal and control groups, but there was no correlation between apelin levels and BMI index.…”

Section: Discussioncontrasting

confidence: 58%

“…It is known to have endocrine and neurotransmitter effects Apelin expression in fat cells is suppressed by starvation and has similar effects on insulin following feeding. 11,12 It has been reported that apelin gene expression in fat tissue is stimulated by insulin and TNF-α Apelin is both synthesized and secreted in fat tissue. 13 Experimental animal studies have shown increased skeletal glucose use and reduced plasma glucose levels after apelin injection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

Fakıoğlu¹,

Yiğitbaşı²,

Emekli³

2017

actapharm

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

Fakıoğlu¹,

Yiğitbaşı²,

Emekli³

2017

actapharm

View full text Add to dashboard Cite

“…10,31 Apelin-IR was previously detected in human plasma using commercially available apelin-36 RIA or apelin-12 EIA kits, [32][33][34][35][36] but the data revealed an important disparity in the concentra- Figure 2. Effects of a 2-h hypertonic saline infusion (0.85 M, 0.06 ml/kg per min) on plasma osmolality (A) and plasma AVP (B) and apelin (C) concentrations.…”

Section: Discussionmentioning

confidence: 99%

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

Azizi

Iturrioz

Blanchard

et al. 2008

Journal of the American Society of Nephrology

119

136

View full text Add to dashboard Cite

Apelin is a neuropeptide that co-localizes with vasopressin (AVP) in magnocellular neurons and is involved in body fluid homeostasis. Osmotic stimuli have opposite effects on the regulation of apelin and AVP secretion in animal models, but whether this is true in humans is unknown. This study investigated the relationship among osmolality, apelin, and AVP in 10 healthy men after infusion of hypertonic saline or loading with water to increase and decrease plasma osmolality, respectively. Increasing plasma osmolality was accompanied by a parallel, linear increase in plasma AVP concentration and by a decrease in plasma apelin concentration. In contrast, decreasing plasma osmolality by water loading reduced plasma AVP concentration and rapidly increased plasma apelin concentration. These findings suggest that regulation of apelin secretion contributes to the maintenance of body fluid homeostasis. The osmotic pressure of body fluids is maintained within a remarkably narrow range in healthy adults. Body fluid homeostasis depends on neuronal pathways bearing very sensitive osmoreceptors, 1 located along the lamina terminalis, including the circumventricular organs, such as the subfornical organ and the organum vasculosum of the lamina terminalis as well as the median preoptic nucleus. 2 The subfornical organ and organum vasculosum of the lamina terminalis are neuronally interconnected with each other as well as with the median preoptic nucleus and the hypothalamic paraventricular and supraoptic nuclei. 3 These neuronal pathways convert small changes in osmolality into a neuronal signal to neurons that influence sensations of thirst and systemic arginine vasopressin (AVP) release, 2 thereby adjusting the intake or output of water to counteract changes in solute concentration. 4,5 A recently discovered peptide, apelin, may also play a major role in the maintenance of body fluid homeostasis. Apelin, initially isolated from bovine stomach extracts, 6 is the endogenous ligand of the human orphan G protein-coupled receptor APJ (putative receptor protein related to the angiotensin receptor AT1). 6,7 It is a 36 -amino acid peptide (apelin 36) derived from a single 77-amino acid precursor, proapelin. 6,8,9 Proapelin has a fully conserved C-terminal 17-amino acid sequence, apelin 17 (K17F), including the pyroglutamyl form of apelin 13 (pE13F). K17F and pE13F both are present in rat brain and plasma, 10 and apelin 36 is present in testis and uterus. 11 All peptides exhibit a high affinity for the human 8,12,13 and the rat apelin receptors. 14 Apelin possesses various cardiovascular functions (for reviews, [15][16][17] ). Apelin and its receptor have been detected in the endothelial cells of large conduit arteries, coronary vessels, and the endocar-

show abstract

“…Fasting plasma apelin levels are reported to be increased in obese subjects (Boucher et al 2005, Heinonen et al 2005 and to correlate positively with BMI (Heinonen et al 2005). However, the prevalence of OSA in these subjects was not documented.…”

Section: Discussionmentioning

confidence: 99%

Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy

Henley¹,

Buchanan²,

Gibson³

et al. 2009

Journal of Endocrinology

View full text Add to dashboard Cite

Apelin is a peptide hormone with cardiovascular and glucose homeostasis properties, and obstructive sleep apnea (OSA) is complicated by cardiovascular and metabolic comorbidities. Plasma apelin has not been previously assessed in OSA. We investigated the response of plasma apelin to a 2-h 75 g oral glucose tolerance test (OGTT) and the effect of 3 months compliant continuous positive airway pressure (CPAP) therapy in 15 obese males with newly diagnosed OSA. Plasma apelin and serum cortisol were recorded 10 minutely, while serum insulin and glucose were measured 30 minutely. Ten subjects had plasma apelin measured at intervals across a 24-h period to investigate for circadian variation in apelin levels, and this was repeated following 3 months compliant CPAP therapy. Fasting (0 . 342G0 . 038 vs 0 . 288 G0 . 024 ng/ml, PZ0 . 04), 30 min (0 . 399G0 . 035 vs 0 . 312 G0 . 036 ng/ml, PZ0 . 007) and 120 min (0 . 402G0 . 030 vs 0 . 259G0 . 024 ng/ml, P!0 . 001) apelin levels were reduced following CPAP. The area under curve for apelin OGTT response was lower post-CPAP (44 . 1G3 . 3 vs 35 . 8 G2 . 3 ng/ml per min, P!0 . 001). Mean OGTT apelin levels showed a significant treatment effect (PZ0 . 006) and a time effect (P!0 . 001), and the effect of time was different preversus post-CPAP (PZ0 . 005). No significant variability in apelin levels existed across the 24-h period at diagnosis. Lower levels were evident overnight following treatment (PZ0 . 004). Improvements in insulin and glucose parameters and reduced cortisol levels were found post-CPAP. In summary, untreated OSA was associated with elevated plasma apelin levels, altered apelin secretory dynamics in response to oral glucose and lack of an apparent circadian variability, which was restored following CPAP.

show abstract

Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding

Cited by 210 publications

References 45 publications

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy

Contact Info

Product

Resources

About