Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis
Hongryeol Park,
Jian Song,
Hyun-Woo Jeong
et al.
Abstract:Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord. Here, we show that treatment with apelin, a secreted peptide ligand for the G protein-coupled receptor APJ/Aplnr, is protective in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Apelin reduces immune cell entry into the brain, delays the onset and reduces the severity of … Show more
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