Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure

Seifirad, Soroush; Masoudkabir, Farzad

doi:10.1016/j.mehy.2013.08.001

Cited by 6 publications

(3 citation statements)

References 39 publications

(55 reference statements)

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“…It has been shown that increased oxidative stress could enhance prevalence of malignancies by direct cellular damage, Seifirad et al (2012); Lu et al (2013); Seifirad and Masoudkabir (2013) however, as mentioned above oxidative stress when applied as immune system arms could protect organisms from invading pathogens and malignant cells (Weel et al, 1996). …”

Section: Oxidative Stress: a Double-edged Swordmentioning

confidence: 99%

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

2014

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Section: Oxidative Stress: a Double-edged Swordmentioning

confidence: 99%

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

2014

Self Cite

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“…Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction [ 8 ]. Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients

Ding

Zhang

et al. 2015

J Transl Med

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BackgroundApelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum apelin affect the left ventricular hypertrophy (LVH) prevalence in hypertensive patients remains unknown.MethodsWe enrolled 344 untreated hypertensive patients. The presence of LVH was determined by echocardiography. The blood was drawn from these patients and serum apelin level was detected. To study the direct effect of apelin on cardiac hypertrophy, cardiomyocytes were cultured and were transfected with apelin gene. Morphometric analysis and measurement of protein contain per cell were then performed.ResultsWe observed a significantly lower serum apelin level in hypertensive patients with LVH compared with those without LVH. Receiver operating characteristic analyses shows that serum apelin level is robust in discriminating patients with LVH from those without. Our in vitro study showed that cellular protein content and cellular size was increased by Ang II treatment, which can be markedly inhibited by the apelin over-expression in cultured cardiomyocytes.ConclusionOur clinical date established a link between apelin and LVH, suggesting serum apelin may be used as a predicator for LVH prevalence in hypertensive patients. The direct evidence in vitro suggest apelin pathway is involved in the cardiomyocyte adaption to hypertrophic stimuli.

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“…It has been shown that ROS have toxic effects to both normal and abnormal cells (infected by intracellular pathogens and malignant cells). It has been shown that increased oxidative stress could enhance prevalence of malignancies by direct cellular damage, [78][79][80] however, oxidative stress when applied as immune system arms could protect organisms from invading pathogens and malignant cells [81].…”

Section: Free Radicals and Cancermentioning

confidence: 99%

Natural Antioxidants as Defense System Against Cancer

Chahal

Saini

Chhillar

et al. 2018

Asian J Pharm Clin Res

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In living cells, the production of free radicals that comprise both reactive oxygen species (ROS) and reactive nitrogen species is highly regulated that help the cells to sustain redox homeostasis. Overproduction of ROS from mitochondrial electron transport chain leakage or excessive stimulation of xanthine oxidase and other oxidative enzymes leads to the uncontrolled production of free radicals leading to oxidative stress that can mediate damage to cell structures. This damage can be repaired by the antioxidant defense system. Antioxidants are capable of stabilizing, or deactivating, free radicals before they attack cellular components such as DNA, proteins, and lipids. The use of antioxidants in cancer prevention is a rapidly evolving research area where antioxidants scavenge free radicals and thus, indirectly help in the prevention of cancer. A wide range of antioxidants such as glutathione, N-acetylcysteine, coenzyme Q10, lycopene, flavonoids, and isoflavones when used in combination with chemotherapy and radiotherapy, result in the reduction of drug toxicity and enhanced efficacy of anticancer agents. This review aims at the use of these exogenous antioxidants as disease-oriented therapy and elucidating the relation of antioxidant enzymes with different types of cancers to overcome the harmful effects of cancer treatment.

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Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure

Cited by 6 publications

References 39 publications

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients

Natural Antioxidants as Defense System Against Cancer

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