Apelin/APJ system: A novel promising target for anti-aging intervention

Zhou, Qi; Chen, Linxi; Tang, Mingzhu; Guo, Yu

doi:10.1016/j.cca.2018.10.011

Cited by 33 publications

(20 citation statements)

References 96 publications

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“…Other exciting discoveries in recent years has been the evidence that APLN/APJ pathway is fundamental in aging: senescence is characterized by lower levels of APLN/APJ and this alteration is associated with impairment of cardiac contractility but above all with inflammation and oxidative stress [110,111]: Apelin treatment alleviates aging damage as demonstrated by Yang et al and Rai et al [112,113]. Interestingly, numerous data reveal that APLN amplifies exercise benefits: in old mice model and in humans, exercise improving APLN expression ameliorates skeletal and cardiac dysfunctions and moreover exercise-induced APLN improves cognitive functions [114][115][116].…”

Section: Apelin/apj Axis: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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Section: Apelin/apj Axis: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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“…APJ is considered an emerging therapeutic target for a variety of disease indications (49)(50)(51)(52). We show here that it is feasible to develop a potent small-molecule agonist suitable for clinical studies.…”

Section: Discussionmentioning

confidence: 82%

“…HF remains a leading cause of death worldwide, and new medications are desperately needed to manage disease progression. The apelin/APJ axis is a novel pathway implicated in a variety of diseases, including HF (49)(50)(51)(52). Given the short half-life of the endogenous peptide ligands, a key question remained related to the feasibility of developing a safe and effective small-molecule APJ agonist.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular response to small-molecule APJ activation

Ason¹,

Chen²,

Guo³

et al. 2020

JCI Insight

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“…Apelin, a 77-amino acid peptide secreted by white adipose tissue, functions as the endogenous ligand for the human orphan G protein-coupled receptor (APJ) [19]. It was revealed that the apelin-APJ system plays an essential role in the cardiovascular system, heart development, and was related inversely to the process of arterial atherosclerosis [20][21][22][23]. Apelin-12, one of the most potent apelin peptides, is involved in the regulation of body fluid homeostasis and has a positive inotropic action in failing myocardium [24,25].…”

Section: Introductionmentioning

confidence: 99%

A Nomogram Based on Apelin-12 for the Prediction of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention among Patients with ST-Segment Elevation Myocardial Infarction

Zhao

Xie

Zhang

2020

Cardiovascular Therapeutics

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Objective. This study aimed to establish a clinical prognostic nomogram for predicting major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention (PCI) among patients with ST-segment elevation myocardial infarction (STEMI). Methods. Information on 464 patients with STEMI who performed PCI procedures was included. After removing patients with incomplete clinical information, a total of 460 patients followed for 2.5 years were randomly divided into evaluation (n = 324) and validation (n = 136) cohorts. A multivariate Cox proportional hazards regression model was used to identify the significant factors associated with MACEs in the evaluation cohort, and then they were incorporated into the nomogram. The performance of the nomogram was evaluated by the discrimination, calibration, and clinical usefulness. Results. Apelin-12 change rate, apelin-12 level, age, pathological Q wave, myocardial infarction history, anterior wall myocardial infarction, Killip’s classification > I, uric acid, total cholesterol, cTnI, and the left atrial diameter were independently associated with MACEs (all P<0.05). After incorporating these 11 factors, the nomogram achieved good concordance indexes of 0.758 (95%CI = 0.707–0.809) and 0.763 (95%CI = 0.689–0.837) in predicting MACEs in the evaluation and validation cohorts, respectively, and had well-fitted calibration curves. The decision curve analysis (DCA) revealed that the nomogram was clinically useful. Conclusions. We established and validated a novel nomogram that can provide individual prediction of MACEs for patients with STEMI after PCI procedures in a Chinese population. This practical prognostic nomogram may help clinicians in decision making and enable a more accurate risk assessment.

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Apelin/APJ system: A novel promising target for anti-aging intervention

Cited by 33 publications

References 96 publications

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Cardiovascular response to small-molecule APJ activation

A Nomogram Based on Apelin-12 for the Prediction of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention among Patients with ST-Segment Elevation Myocardial Infarction

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