Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock
William Salvail,
Dany Salvail,
Frédéric Chagnon
et al.
Abstract:Background
Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial dysfunction. However, sustained catecholamine infusion is linked to cardiac toxicity and impaired responsiveness. Several pre-clinical and clinical studies have investigated the use of alternative vasopressors in the treatment of septic shock, with limited benefits and generally no effect on mortality. Apelin-13 (APL-13) is an endogenous positive… Show more
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