APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production

Wang, Feng Wei; Cao, Chenhui; Han, Kai; Zhao, Yong; Cai, Mu Yan; Xiang, Zhi Cheng; Zhang, Jia Xing; Chen, Jie Wei; Zhong, Li; Huang, Yong; Zhou, Su Fang; Jin, Xiaoyue; Guan, Xin Yuan; Xu, Rui‐Hua; Xie, Dan

doi:10.1172/jci122478

Cited by 125 publications

(114 citation statements)

References 44 publications

(56 reference statements)

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“…To abate angiogenesis remains a severe challenge for tumor treatment. Wang et al . examined the expression of lncRNA‐APC1 and unveiled that lncRNA‐APC1 activated by APC suppressed CRC angiogenesis via targeting Rab5b mRNA, which could inhibit tumor angiogenesis in CRC (Table ).…”

Section: Exosome and Tumor Developmentmentioning

confidence: 99%

“…54 To abate angiogenesis remains a severe challenge for tumor treatment. Wang et al 55 examined the expression of lncRNA-APC1 and unveiled that lncRNA-APC1 activated by APC suppressed CRC angiogenesis via targeting Rab5b mRNA, which could inhibit tumor angiogenesis in CRC (Table 1). This finding advances our understanding of APCregulated lncRNA-APC1 procedure which downregulates angiogenesis provides an exploitable therapeutic approach for CRC.…”

Section: Cancer Metastasismentioning

confidence: 99%

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The cancer exosomes: Clinical implications, applications and challenges

Tang

Hou

et al. 2019

Intl Journal of Cancer

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The exosome is a small functional vesicle enriched in selected proteins, lipids and nucleic acids, displaying distinct molecular heterogeneity. Exosomes released can transform the extracellular matrix microenvironments, transmit signals and molecules to recipient cells and trigger changes in their pathophysiological functions. Tumor‐derived exosomes mediate the interactions of tumor cells and microenvironment significantly, and they stimulate tumor growth and development through specific signaling pathways related to metastasis, therapeutic resistance and immunosuppression. Exosome biogenesis from tumors often represents abundant biological information, and novel and efficient isolation and detection methods of exosomes provide a promising approach for tumor diagnosis and prognosis estimation. Moreover, exosome can even be developed as therapeutic agents for multiple disease models based on effective material transport characteristics and biofilm specificity. This review reports the clinical implications and challenges of exosomes in cancer progression, therapy resistance, metastasis and immune escape, and underlying cancerogenic pathological phenotypes including fibrosis and viral infection.

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Section: Exosome and Tumor Developmentmentioning

confidence: 99%

Section: Cancer Metastasismentioning

confidence: 99%

The cancer exosomes: Clinical implications, applications and challenges

Tang

Hou

et al. 2019

Intl Journal of Cancer

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“…In this issue of the JCI, Wang et al describe an entirely new pathway for APC function (20). First, they identified a novel lncRNA that they named lncRNA-APC1, which is upregulated by WT APC expression and appears to be independent of the canonical Wnt pathway.…”

Section: A New Pathway For Apc Functionmentioning

confidence: 99%

Colorectal cancer: the APC-lncRNA link

Morin¹

2019

Journal of Clinical Investigation

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“…Recently, it is increasingly recognized that long-noncoding RNAs (lncRNAs) constitute an important component in the regulation of cellular development, differentiation, and many other biological processes. [9][10][11] LncRNAs are dysregulated in various cancers, indicating both tumor-suppressive and oncogenic roles, thus suggesting that aberrant expression of lncRNAs may contribute to cancer development. 12,13 Drawing on a review of published studies, [14][15][16][17][18][19][20] it enlightens us that lncRNA CRNDE and lncRNA SNHG7, two oncogenes, may be promising biomarkers of SCLM prognosis.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA CRNDE and lncRNA SNHG7 are Promising Biomarkers for Prognosis in Synchronous Colorectal Liver Metastasis Following Hepatectomy</p>

Zhang

Shi

Song

et al. 2020

CMAR

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Synchronous colorectal liver metastasis (SCLM) had limited availability of tools to predict survival and tumor recurrence. LncRNA CRNDE and lncRNA SNHG7 have been proven to be closely related to cancer progression. However, the predictive value of lncRNA CRNDE and lncRNA SNHG7 in cancer prognosis is still unclear. The purpose of this study was to investigate whether lncRNA CRNDE and lncRNA SNHG7 could be used as promising biomarkers for prognosis prediction of SCLM patients who underwent hepatectomy. Methods: The expression profile of lncRNA CRNDE and lncRNA SNHG7 in serum of SCLM patients was examined by qRT-PCR. The relationship between lncRNA expression and clinicopathological characteristics was analyzed. The Cox proportional-hazards regression model and Kaplan-Meier analysis were performed to analyze the association between lncRNA expression and overall survival (OS) and tumor recurrence of SCLM patients. Results: Levels of lncRNA CRNDE and lncRNA SNHG7 in patients who underwent recurrence or death were significantly higher than that of patients with recurrence-free or survival (P<0.01). Both lncRNA CRNDE high level and lncRNA SNHG7 high level showed a significant correlation with differentiation of primary tumor, invasion depth of primary focus, lymph node metastases, number of liver metastases, and liver metastasis grade. High levels of lncRNA CRNDE or lncRNA SNHG7 predicted shorter recurrence time, shorter OS time, higher recurrence rate and lower OS rate. Furthermore, lncRNA CRNDE and lncRNA SNHG7 were independent risk factors for high recurrence and poor OS in SCLM underwent hepatectomy. Conclusion: Taken together, lncRNA CRNDE and lncRNA SNHG7 could be promising biomarkers for prediction of OS and tumor recurrence in SCLM underwent hepatectomy.

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APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production

Cited by 125 publications

References 44 publications

The cancer exosomes: Clinical implications, applications and challenges

The cancer exosomes: Clinical implications, applications and challenges

Colorectal cancer: the APC-lncRNA link

<p>LncRNA CRNDE and lncRNA SNHG7 are Promising Biomarkers for Prognosis in Synchronous Colorectal Liver Metastasis Following Hepatectomy</p>

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