Apatite bone cement reinforced with calcium silicate fibers

Motisuke, Mariana; Santos, Verônica R.; Bazanini, Naiana C.; Bertran, Celso Aparecido

doi:10.1007/s10856-014-5280-7

Cited by 17 publications

(13 citation statements)

References 33 publications

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“…To finalize this topic, one should mention that CaPO 4 might be added into self-setting calcium sulfate (plaster of Paris) formulations to improve their osteoconductivity [ 508 , 509 ]. Similarly, calcium silicates could be added to the self-setting CaPO 4 formulations [ 510 , 511 , 512 , 513 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

125

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

125

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“…The mechanical properties of α -TCP-based CPC can be enhanced by the addition of WF (CaSiO 3 ) [ 14 ]. This raises the possibility of increasing the bioactivity of CPC through the release of silicon during wollastonite hydrolysis.…”

Section: Introductionmentioning

confidence: 99%

“…This raises the possibility of increasing the bioactivity of CPC through the release of silicon during wollastonite hydrolysis. Motisuke et al [ 14 ] found that addition of 5% (w/w) WF reinforces the compressive strength of an apatite CPC by 250% compared to nonreinforced CPC (from 14.5 to 50.4 MPa). Wollastonite exhibits excellent in vitro bioactivity [ 15 ], as demonstrated by the relatively rapid formation of an apatite layer on its surface compared to other bioactive materials (e.g., bioactive glass).…”

Section: Introductionmentioning

confidence: 99%

Addition of Wollastonite Fibers to Calcium Phosphate Cement Increases Cell Viability and Stimulates Differentiation of Osteoblast-Like Cells

Domingues

Motisuke

Bertran

et al. 2017

The Scientific World Journal

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Calcium phosphate cement (CPC) that is based on α-tricalcium phosphate (α-TCP) is considered desirable for bone tissue engineering because of its relatively rapid degradation properties. However, such cement is relatively weak, restricting its use to areas of low mechanical stress. Wollastonite fibers (WF) have been used to improve the mechanical strength of biomaterials. However, the biological properties of WF remain poorly understood. Here, we tested the response of osteoblast-like cells to being cultured on CPC reinforced with 5% of WF (CPC-WF). We found that both types of cement studied achieved an ion balance for calcium and phosphate after 3 days of immersion in culture medium and this allowed subsequent long-term cell culture. CPC-WF increased cell viability and stimulated cell differentiation, compared to nonreinforced CPC. We hypothesize that late silicon release by CPC-WF induces increased cell proliferation and differentiation. Based on our findings, we propose that CPC-WF is a promising material for bone tissue engineering applications.

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“…Recently, the calcium silicate (CaSiO 3 , CS) ceramics and their composites are investigated as potentially new type of bioceramics for bone regeneration and bone tissue engineering applications [2][3][4][5][6][7][8][9][10][11][12][13][14]. Previous studies have confirmed that the CS bioceramics possess excellent bioactivity and biodegradability [12], and in vitro cell culture studies have shown that the CS bioceramics well supported the attachment and proliferation of bone marrow mesenchymal stem cells (BMSCs) and osteoblasts [11,13,15], and the bioactive Si ions released from CS provided a preferable extracellular environment for directing BMSCs proliferation and differentiation toward the osteogenic lineage [9], and enhancing the proliferation and angiogenesis process of the human umbilical vein endothelial cells (HUVECs) [3].…”

Section: Introductionmentioning

confidence: 99%

Degradation and silicon excretion of the calcium silicate bioactive ceramics during bone regeneration using rabbit femur defect model

Lin

Liu

Huang

et al. 2015

J Mater Sci: Mater Med

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The investigation of the bone regeneration ability, degradation and excretion of the grafts is critical for development and application of the newly developed biomaterials. Herein, the in vivo bone-regeneration, biodegradation and silicon (Si) excretion of the new type calcium silicate (CaSiO3, CS) bioactive ceramics were investigated using rabbit femur defect model, and the results were compared with the traditional β-tricalcium phosphate [β-Ca3(PO4)2, β-TCP] bioceramics. After implantation of the scaffolds in rabbit femur defects for 4, 8 and 12 weeks, the bone regenerative capacity and degradation were evaluated by histomorphometric analysis. While urine and some organs such as kidney, liver, lung and spleen were resected for chemical analysis to determine the excretion of the ionic products from CS implants. The histomorphometric analysis showed that the bioresorption rate of CS was similar to that of β-TCP in femur defect model, while the CS grafts could significantly stimulate bone formation capacity as compared with β-TCP bioceramics (P < 0.05). The chemical analysis results showed that Si concentration in urinary of the CS group was apparently higher than that in control group of β-TCP. However, no significant increase of the Si excretion was found in the organs including kidney, which suggests that the resorbed Si element is harmlessly excreted in soluble form via the urine. The present studies show that the CS ceramics can be used as safe, bioactive and biodegradable materials for hard tissue repair and tissue engineering applications.

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Apatite bone cement reinforced with calcium silicate fibers

Cited by 17 publications

References 33 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Addition of Wollastonite Fibers to Calcium Phosphate Cement Increases Cell Viability and Stimulates Differentiation of Osteoblast-Like Cells

Degradation and silicon excretion of the calcium silicate bioactive ceramics during bone regeneration using rabbit femur defect model

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