Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease

Robert, Philippe; Berr, Claudine; Volteau, Magali; Bertogliati, C.; Benoît, Michel; Sarazin, Marie; Legrain, S.; Dubois, Bruno

doi:10.1016/j.clineuro.2006.02.003

Cited by 178 publications

(156 citation statements)

References 26 publications

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“…The largest of these groups was the Executive and Initiation apathy subgroup (N=43), which was reinforced by people with AD and controls self-rating group comparison and magnitude of difference between the Executive and Initiation apathy subscales. As one of the most prominent behavioral symptoms in AD, cognitive impairment is also associated with apathy [45][46][47]. While memory impairment is common in AD, attention [48] and executive dysfunction [49], such as planning, spatial navigation attention [50][51][52] and verbal fluency [53] are also particularly noted to be impaired as the disease progresses to later stages, which is particularly relevant to our sample which is more impaired.…”

Section: Discussionmentioning

confidence: 69%

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

Radaković

Starr

Abrahams

2017

JAD

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Section: Discussionmentioning

confidence: 69%

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

Radaković

Starr

Abrahams

2017

JAD

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“…We did not find that the predictive accuracy of depressive symptoms for AD was dependent on follow-up length, although population-based studies did show that the risk of developing AD for those with depressive symptoms either increased or decreased with follow-up length (Green et al 2003 ;Ownby et al 2006). Anxiety was found to be associated with a decreased risk for AD in two other studies as well (Robert et al 2006 ;Liu et al 2007) ; but a populationbased study reached the opposite conclusion (Palmer et al 2007). These conflicting findings may be explained by a difference in setting.…”

Section: Discussionmentioning

confidence: 83%

“…These symptoms are common in subjects with MCI (Apostolova & Cummings, 2007), but it is uncertain whether they can predict AD in this population (Steffens et al 2006). Depressive symptoms were associated with an increased risk of developing AD in some studies (Modrego & Ferrandez, 2004 ;Gabryelewicz et al 2007), and with a decreased risk in others (Rozzini et al 2005 ;Liu et al 2007), while most studies did not find a relationship between depression and AD at all (Tierney et al 1999 ;Visser et al 2000a, b ;Copeland et al 2003 ;Korf et al 2004 ;Robert et al 2006 ;Wang et al 2006 ;Feldman et al 2007 ;Palmer et al 2007 ;Teng et al 2007 ;Panza et al 2008). Similarly, discrepant results have been reported regarding the predictive accuracy of apathy and anxiety for AD (Robert et al 2006 ;Feldman et al 2007 ;Liu et al 2007 ;Palmer et al 2007 ;Teng et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

et al. 2009

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Background. Affective symptoms are common in subjects with mild cognitive impairment (MCI), but there is disagreement whether these symptoms are predictive for Alzheimer's disease (AD). We investigated the predictive accuracy of affective symptoms for AD during a follow-up study in subjects with MCI, and whether the predictive accuracy was modified by age, the presence of amnestic MCI or the length of follow-up.Method. Newly referred subjects (n=263) with MCI older than 55 years were selected from a memory clinic and followed up after 2, 5 and 10 years. Predictors investigated were : symptoms of depression, anxiety, apathy and sleeping problems.Results. Affective symptoms were present in 50-70 % of the subjects. The average follow-up period was 5.4 years and 79 subjects (29 %) developed AD. Sleeping problems were associated with a decreased risk for AD [odds ratio (OR) 0.35, p<0.001]. Symptoms of depression (OR 0.61, p=0.059) and anxiety (OR 0.58, p=0.051) showed a trend in the same direction. The OR of apathy for AD was 0.67 (p=0.14). Depression was associated with a decreased risk for AD only in subjects without amnestic MCI, but not in subjects with amnestic MCI. Moreover, anxiety was related to the risk for AD differently between subjects diagnosed with AD at the 5-year follow-up (OR 0.23) and subjects diagnosed with AD at the 10-year follow-up (OR 1.7).Conclusions. Affective symptoms are associated with a decreased risk for AD. The risk may be dependent on MCI subtype or length of follow-up, but it does not depend on age.

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“…2 Apathy can also exist in the preclinical phase of AD, alerting the clinician to a possible progression toward this disease. 3 Moreover, a longitudinal study by Starkstein et al 4 showed that apathy in AD was a significant predictor of a faster cognitive, functional, and emotional decline.…”

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confidence: 99%

Apathy and Executive Dysfunction in Alzheimer Disease

Esposito

Rochat

Linden

et al. 2010

Alzheimer Disease &Amp; Associated Disorders

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Apathy, defined as a reduction in voluntary goal-directed behaviors, is one of the most common behavioral symptoms encountered in Alzheimer disease (AD). However, the processes underlying the different components of apathy are still unclear. The aim of this study was to explore a particularly important aspect of executive function in daily life: multitasking [assessed with the Modified Six Elements Task (MSET)], and its relationship with apathy in AD. Sixty-seven participants (37 AD patients matched with 30 control participants) were screened using the MSET. Simultaneously, a close relative of each patient was given the Apathy Inventory, which assesses 3 distinct dimensions of apathy (lack of initiative, lack of interest, and emotional blunting). AD patients presented significantly more multitasking deficits than control participants. In addition, regression analyses revealed that the number of rule breaks on the MSET (inability to perform several tasks in a predefined time observing a number of rules) was the best predictor of apathy, and especially of lack of initiative. These results suggest that the relation between lack of initiative and multitasking has a specific character and that mechanisms underlying multitasking constitute a key component of goal-directed behaviors.

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Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease

Cited by 178 publications

References 26 publications

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

Apathy and Executive Dysfunction in Alzheimer Disease

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