Apathy in Alzheimer's disease

Nobis, Lisa; Husain, Masud

doi:10.1016/j.cobeha.2017.12.007

Cited by 96 publications

(68 citation statements)

References 43 publications

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“…This pattern of multidimensional apathy may not be specific to PD, and future investigations could focus on other conditions in which apathy is prevalent such as Alzheimer's disease20 and schizophrenia 21. Theoretically, other psychiatric and neurological disorders might show different patterns of associations within the profile of apathy.…”

Section: Discussionmentioning

confidence: 93%

Differential impact of behavioral, social, and emotional apathy on Parkinson's disease

Ang

Lockwood

Kienast

et al. 2018

Ann Clin Transl Neurol

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Apathy is highly prevalent in Parkinson's disease. New findings suggest the syndrome is multifaceted. Here, we investigate whether all aspects of apathy are equally affected in Parkinson's disease and whether different dimensions of apathy were associated with depression and anhedonia. On the Apathy Motivation Index, while behavioral apathy and social apathy were elevated, emotional motivation was relatively preserved in Parkinson's disease, although a few patients did show impaired emotional sensitivity. Behavioral and social, but not emotional, apathy was associated with depression and anhedonia. These findings suggest aspects of motivation can be selectively impaired in Parkinson's disease and may have implications for guiding treatment.

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Section: Discussionmentioning

confidence: 93%

Differential impact of behavioral, social, and emotional apathy on Parkinson's disease

Ang

Lockwood

Kienast

et al. 2018

Ann Clin Transl Neurol

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“…One potential barrier to using hobbies as a motivator is the effect of apathy on motivation. Apathy is a major neuropsychiatric symptom in dementia and is sometimes observed in patients with MCI [ 17 ]. Individuals with clinical apathy would be less likely to be motivated by the type of training described.…”

Section: Discussionmentioning

confidence: 99%

A Novel Auditory-Cognitive Training App for Delaying or Preventing the Onset of Dementia: Participatory Design With Stakeholders

Frost¹,

Porat²,

Malhotra³

et al. 2020

JMIR Hum Factors

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Background Multiple gaming apps exist under the dementia umbrella for skills such as navigation; however, an app to specifically investigate the role of hearing loss in the process of cognitive decline is yet to be designed. There is a demonstrable gap in the utilization of games to further the knowledge of the potential relationship between hearing loss and dementia. Objective This study aims to identify the needs, facilitators, and barriers in designing a novel auditory-cognitive training gaming app. Methods A participatory design approach was used to engage key stakeholders across audiology and cognitive disorder specialties. Two rounds, including paired semistructured interviews and focus groups, were completed and thematically analyzed. Results A total of 18 stakeholders participated, and 6 themes were identified to inform the next stage of app development. These included congruence with hobbies, life getting in the way, motivational challenge, accessibility, addictive competition, and realism. Conclusions The findings can now be implemented in the development of the app. The app will be evaluated against outcome measures of speech listening in noise, cognitive and attentional tasks, quality of life, and usability.

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“…The frontostriatal circuit, linking the ventral striatum to the dorsal ACC via the ventral pallidum and thalamus, is believed to be crucially involved in effort-based decision-making and executive functions. Disruptions in this circuit have been hypothesized to play a critical role in apathy across neurodegenerative disorders (19). Amyloid-b (Ab) deposition, a pathological characteristic of AD, has also been shown to correlate positively with apathy (20).…”

Section: Discussionmentioning

confidence: 99%

Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial

Kuroda

Matsuzaki

Wakatsuki

et al. 2019

J Nutr Sci Vitaminol

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Brown rice contains many ingredients that might protect against cognitive decline and Alzheimer's disease. However, brown rice is very hard, difficult to cook, and is poorly digested; thus, it is difficult to eat long-term. To solve these problems, ultra-high hydrostatic pressurizing brown rice (UHHPBR) was prepared. We investigated the effects of dietary UHHPBR administration for 24 mo on cognitive function and mental health in the elderly. Healthy elderly participants (n552) were randomized into UHHPBR and polished white rice (WR) groups. The UHHPBR group consumed 100 g of UHHPBR per day for 24 mo and the WR group consumed white rice. At baseline, and after 12 and 24 mo, cognitive functions were assessed using the Revised Hasegawa's Dementia Scale, Mini-Mental State Examination, Frontal Assessment Battery (FAB), and the Cognitive Assessment for Dementia, iPad version (CADi). Mental health condition was also assessed using the Apathy Scale and the Zung Self-Rating Depression Scale, and serum biochemical parameters were determined. From baseline to month 24, the mean change in the FAB-sub item 1 scores was higher in the UHHPBR group compared to the WR group. Furthermore, apathy scores decreased, as well as the time required to answer all questions of the CADi, and plasma epinephrine levels increased. These results indicate that a 2-y oral consumption of UHHPBR increases information processing speed (as a measure of cognitive function) and improves apathy in the elderly, suggesting a protective effect of UHHPBR administration against agerelated decline in brain cognition and motivation.

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Apathy in Alzheimer's disease

Cited by 96 publications

References 43 publications

Differential impact of behavioral, social, and emotional apathy on Parkinson's disease

Differential impact of behavioral, social, and emotional apathy on Parkinson's disease

A Novel Auditory-Cognitive Training App for Delaying or Preventing the Onset of Dementia: Participatory Design With Stakeholders

Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial

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