Apathy and Prospective Memory in Aging

Esposito, Fabienne; Rochat, Lucien; Linden, Anne-Claude Juillerat Van der; Linden, Martial Van der

doi:10.1159/000345037

Cited by 16 publications

(8 citation statements)

References 75 publications

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“…Several studies have demonstrated that the n-back paradigm provides a valid measure of working memory updating (Jaeggi, Buschkuehl, Perrig, & Meier, 2010) and is sensitive to deficits after TBI (Perlstein et al, 2004). In addition, this component of working memory has been specifically related to multitasking performance (Rose et al, 2015), and several studies have shown that working memory is involved in apathy (e.g., Esposito, Rochat, Juillerat Van der Linden, & Van der Linden, 2012).…”

Section: -Back 'Working Memory' Taskmentioning

confidence: 99%

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

Arnould

Rochat

Dromer

et al. 2016

Journal of Neuropsychology

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Apathy is frequently described in patients with traumatic brain injury (TBI); its negative consequences particularly affect functional independence. Among apathetic manifestations, lack of initiative and lack of interest have mainly been associated with cognitive impairments. However, few studies have been conducted to precisely identify the underlying cognitive processes. Our aims were (1) to determine the best predictor of apathy from among several cognitive processes, including episodic memory and attention/executive mechanisms and multitasking, and (2) to examine to what extent multitasking could mediate the relationships between specific cognitive processes and lack of initiative/interest. Seventy participants (34 patients with TBI matched with 36 control participants) were given a questionnaire to assess anxio-depressive symptoms, four tasks to assess specific cognitive processes, and one task to assess real-life multitasking. Participants' relatives completed an apathy questionnaire. Multitasking, as assessed by the number of goals not achieved, was the only significant predictor of apathetic manifestations. In addition, the mediation analyses revealed that multitasking performance mediated the relationships between verbal episodic memory and lack of initiative/interest, whereas executive and attentional functions were only indirectly related to lack of initiative/interest due to their significant impacts on multitasking. These results shed new light on the aetiology of apathetic manifestations in patients with TBI, indicating how specific cognitive deficits are expressed in real-life multitasking, and consequently, how they may lead to the development and/or maintenance of apathetic manifestations.

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Section: -Back 'Working Memory' Taskmentioning

confidence: 99%

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

Arnould

Rochat

Dromer

et al. 2016

Journal of Neuropsychology

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“…There also is shared pathophysiology between apathy and executive dysfunction involving frontal lobe regions (Holthoff et al, 2005; Rosen et al, 2005). Additionally, apathy has been associated with other cognitive deficits, including aspects of memory (Esposito, Rochat, Juillerat Van der Linden, & Van der Linden, 2012), and frequently occurs in individuals with memory and other cognitive impairments (e.g., MCI and Alzheimer’s disease; Geda et al, 2013). Similarly, previous studies have demonstrated associations between depression and cognitive impairment in older adults.…”

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confidence: 99%

The Independent Contributions of Cognitive Impairment and Neuropsychiatric Symptoms to Everyday Function in Older Adults

Rog

Park

Harvey

et al. 2014

The Clinical Neuropsychologist

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The everyday functional capacities of older adults are determined by multiple factors. The primary goal of the present study was to evaluate whether apathy and depression have unique influences on degree of functional impairment, independent of the effects of specific cognitive impairments. Participants included 344 older adults (199 normals, 87 with MCI, 58 with dementia). The Everyday Cognition (ECog) scales were used to measure both global and domain-specific functional abilities. Neuropsychiatric symptoms of depression and apathy were measured by the Neuropsychiatric Inventory (NPI), and specific neuropsychological domains measured included episodic memory and executive functioning. Results indicated that worse memory and executive function, as well as greater depression and apathy, were all independent and additive determinants of poorer functional abilities. Apathy had a slightly more restricted effect than the other variables across the specific functional domains assessed. Secondary analysis suggested that neuropsychiatric symptoms may be more strongly associated with everyday function within cognitively normal and MCI groups, while cognitive impairment is more strongly associated with everyday function in dementia. Thus, a somewhat different set of factors may be associated with functional status across various clinical groups.

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“…lack of initiative) and lack of goal-directed cognitive activity (i.e. lack of interest) [13][14][15]. These data are not surprising since a lack of interest is closely related to a lack of initiative and on the other hand, a lack of initiated actions may gradually lead to a lack of interest.…”

Section: Manifestations Of Apathymentioning

confidence: 92%

“…Furthermore, recent studies have shown the implication of different psychological mechanisms in the various facets of apathy. Thus, in elderly subjects, lack of initiative has been associated with difficulties in the ability to run multiple tasks simultaneously (''multitasking'') [18], difficulties in prospective memory [14] and also low self-efficacy beliefs [19]. To be more precise, Esposito et al [18] showed that the number of rules breaks on the modified Six Elements Test [20] was a significant predictor of lack of initiative in persons with a diagnosis of Alzheimer's disease.…”

Section: Manifestations Of Apathymentioning

confidence: 99%

Neurobehavioral and self-awareness changes after traumatic brain injury: Towards new multidimensional approaches

Arnould

Dromer

Rochat

et al. 2016

Annals of Physical and Rehabilitation Medicine

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Neurobehavioral and self-awareness changes are frequently observed following traumatic brain injury (TBI). These disturbances have been related to negative consequences on functional outcomes, caregiver distress and social reintegration, representing therefore a challenge for clinical research. Some studies have recently been conducted to specifically explore apathetic and impulsive manifestations, as well as self-awareness impairments in patients with TBI. These findings underlined the heterogeneity of clinical manifestations for each behavioral disturbance and the diversity of psychological processes involved. In this context, new multidimensional approaches taking into account the various processes at play have been proposed to better understand and apprehend the complexity and dynamic nature of these problematic behaviors. In addition, the involvement of social and environmental factors as well as premorbid personality traits have increasingly been addressed. These new multidimensional frameworks have the potential to ensure targeted and effective rehabilitation by allowing a better identification and therefore consideration of the various mechanisms involved in the onset of problematic behaviors. In this context, the main objective of this position paper was to demonstrate the interest of multidimensional approaches in the understanding and rehabilitation of problematic behaviors in patients with TBI.

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Apathy and Prospective Memory in Aging

Cited by 16 publications

References 75 publications

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

The Independent Contributions of Cognitive Impairment and Neuropsychiatric Symptoms to Everyday Function in Older Adults

Neurobehavioral and self-awareness changes after traumatic brain injury: Towards new multidimensional approaches

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