Apathy and Emotional Blunting in Parkinson’s Disease

Leroi, Iracema; Perera, Nilika; Harbishettar, Vijay; Robert, Philippe

doi:10.4172/2168-975x.1000141

Cited by 4 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several possible reasons why loneliness of the care partners may have predicted increases in depressive symptoms and anxiety for themselves, but not the MAS attendees. It is possible that due to the disruption of emotion‐specific neural networks in neurodegenerative disorders, detection of the emotional states in others is diminished, 31 , 32 , 33 , 34 disrupting the expected process of recognition of emotional states in others.…”

Section: Discussionmentioning

confidence: 99%

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

Maharani

Zaidi

Jury

et al. 2022

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

Introduction This study examined the long‐term influence of loneliness and social isolation on mental health outcomes in memory assessment service (MAS) attendees and their care partners, with a focus on interdependence and bidirectionality. Methods Longitudinal data from 95 clinic attendees with cognitive impairment, and their care partners (dyads), from four MAS in the North of England were analyzed. We applied the actor–partner interdependence model, seeking associations within the dyad. At baseline and 12‐month follow‐up, clinic attendees and care partners completed measures of loneliness and social isolation, depression, and anxiety. Results Social isolation at baseline was more prevalent in care partners compared to MAS attendees. Social isolation in MAS attendees was associated with higher anxiety symptoms (β = 0.28, 95% confidence intervals [CIs] = 0.11 to 0.45) in themselves at 12 months. We found significant positive actor and partner effects of loneliness on depression (actor effect: β = 0.36, 95% CIs = 0.19 to 0.53; partner effect: β = 0.23, 95% CIs = 0.06 to 0.40) and anxiety (actor effect: β = 0.39, 95% CIs = 0.23 to 0.55; partner effect: β = 0.22, 95% CIs = 0.05 to 0.39) among MAS attendees 1 year later. Loneliness scores of the care partners have a significant and positive association with depressive (β = 0.36, 95% CIs = 0.19 to 0.53) and anxiety symptoms (β = 0.32, 95% CIs = 0.22 to 0.55) in themselves at 12 months. Discussion Loneliness and social isolation in MAS clinic attendees had a downstream effect on their own and their care partners’ mental health. This highlights the importance of including care partners in assessments of mental health and social connectedness and expanding the remit of social prescribing in the MAS context.

show abstract

Section: Discussionmentioning

confidence: 99%

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

Maharani

Zaidi

Jury

et al. 2022

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

show abstract

“…PD apathy is associated with older age, increased levels of depression and lower dopamine agonist use [51][52][53][54], is detrimental to disability and health-related quality of life [50] and is associated with increased caregiver burden [51][52][53][54]. People with PD and apathy are poorer at processing of certain emotions (fear, disgust and happiness) than with those with PD and no apathy [33], and emotional blunting in PD apathy is associated with poorer quality of life and increased caregiver burden [55].…”

Section: Introductionmentioning

confidence: 99%

Apathy as a behavioural marker of cognitive impairment in Parkinson’s disease: a longitudinal analysis

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Understanding the longitudinal course of non-motor symptoms, and finding markers to predict cognitive decline in Parkinson's disease (PD), are priorities. Previous work has demonstrated that apathy is one of the only behavioural symptoms that differentiates people with PD and intact cognition from those with mild cognitive impairment (MCI-PD). Other psychiatric symptoms emerge as dementia in PD develops. Objective We explored statistical models of longitudinal change to detect apathy as a behavioural predictor of cognitive decline in PD. Methods We followed 104 people with PD intermittently over 2 years, undertaking a variety of motor, behavioural and cognitive measures. We applied a linear mixed effects model to explore behavioural factors associated with cognitive change over time. Our approach goes beyond conventional modelling based on a random-intercept and slope approach, and can be used to examine the variability in measures within individuals over time. Results Global cognitive scores worsened during the two-year follow-up, whereas the longitudinal evolution of self-rated apathy scores and other behavioural measures was negligible. Level of apathy was negatively (− 0.598) correlated with level of cognitive impairment and participants with higher than average apathy scores at baseline also had poorer cognition. The model indicated that departure from the mean apathy score at any point in time was mirrored by a corresponding departure from average global cognitive score. Conclusion High levels of apathy are predictive of negative cognitive and behavioural outcomes over time, suggesting that apathy may be a behavioural indicator of early cognitive decline. This has clinical and prognostic implications.

show abstract

“…depression, psychotic symptoms) [78,82] and cognitive decline [5,76,109,110]. Apathy, a common and often under-recognised neuropsychiatric complication of PDD and DLB, is strongly associated with care burden [111], in part due to emotional blunting that is one of the dimensions of the apa0thy syndrome [112].…”

Section: Care Burdenmentioning

confidence: 99%

Long-Term Partnerships in Lewy Body Dementias

Vatter¹,

Leroi²

2019

Geriatric Medicine and Gerontology

Self Cite

View full text Add to dashboard Cite

Long-term partnerships are important as they can determine happiness, influence physical and mental health and lengthen one's lifespan. However, complex neurodegenerative conditions, such as Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), can disrupt long-term relationships and even lead to dissolution of the partnership. The majority of studies in this field have focused on exploring the effect of PDD and DLB on care partners' outcomes but the impact of these conditions on dyadic, long term relationships is less well understood. We conducted a series of studies with people with PDD or DLB and their caregiving life partners using quantitative and qualitative methods. We demonstrated that PDD and DLB has a tremendous impact on the caregiving life partners and reduces relationship satisfaction. We argue for more studies in this field and recommend that future research focuses on strengthening dyadic relationships, which can ultimately preserve relationships and delay institutionalisation of the person with PDD and DLB, which has cost saving implications.

show abstract

Apathy and Emotional Blunting in Parkinson’s Disease

Cited by 4 publications

References 31 publications

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

Apathy as a behavioural marker of cognitive impairment in Parkinson’s disease: a longitudinal analysis

Long-Term Partnerships in Lewy Body Dementias

Contact Info

Product

Resources

About